Identification of Chronotype and its application of non-pharmacological treatment for mood disorders

Research Project

Project/Area Number	24621003
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	睡眠科学
Research Institution	Shiga University of Medical Science
Principal Investigator	YAMADA Naoto 滋賀医科大学, 医学部, 教授 (50166724)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	生体リズム / 時間遺伝子 / 非薬物治療 / 気分障害 / クロノタイプ / 唾液 / 時計遺伝子
Outline of Final Research Achievements	The purpose of the study is to confirm the method for identifying a chrono-type type using saliva from the subjects, and to examine the validity of the method by comparing the data obtained from questionnaire. The saliva of the subjects was collected every 2 hours from 6 to 20 o'clock. After creating the cDNA from the RNA extracted from the saliva, each amount of Per3, Nr1d1, Nr1D2 was measured by the real-time PCR. Then, the index of the circadian rhythm (the acrophase, the mesa - the amplitude) was identified using the data.