| Project/Area Number |
24621005
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
睡眠科学
|
|---|
| Research Institution | Kyushu University (2013-2014)
Kyoto University (2012) |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORI Kiyoshi 京都大学, 大学院医学研究科, 准教授 (60343232)
CHIN Kazuo 京都大学, 大学院医学研究科, 特定教授 (90197640)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 睡眠時無呼吸 / Ngal / 腎障害 / バイオマーカー / 閉塞型睡眠時無呼吸 / 好中球ゼラチラーゼ結合性リポカリン / 血管内皮機能 / 睡眠時無呼吸症候群 / 間欠的低酸素 / 細胞実験 / NGAL / 気道上皮 / 好中球ゼラチラーゼ結合性リポカリン(NGAL) |
|---|
| Outline of Final Research Achievements |
Obstructive sleep apnea (OSA) and a novel lipocalin, neutrophil gelatinase associated lipocalin (Ngal),have been reported to be closely linked with cardiovascular disease and loss of kidney function through chronic inflammation. However, the relationship between OSA and Ngal has never been investigated. In 102 patients, plasma Ngal levels were measured. Ngal levels were reevaluated after three months of treatment in 25 patients.The Ngal level correlated significantly with OSA severity as determined by the apnea hypopnea index and 4% oxygen desaturation index (ODI). Multiple regression analysis showed that the Ngal level was associated with 4%ODI independently of other clinical variables. The Ngal levels were not significantly changed after CPAP.Plasma Ngal levels were positively associated with the severity of OSA. However, it does not seem reasonable to use the Ngal level as a specific biomarker of OSA in clinical practice.
|
