Establishment of plasma neutrophil gelatinase associated lipocalin level as a biomarker in endothelial dysfunction and renal dysfunction in the early stage in patients with obstructive sleep apnea
Project/Area Number |
24621005
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
睡眠科学
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Research Institution | Kyushu University (2013-2014) Kyoto University (2012) |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MORI Kiyoshi 京都大学, 大学院医学研究科, 准教授 (60343232)
CHIN Kazuo 京都大学, 大学院医学研究科, 特定教授 (90197640)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 睡眠時無呼吸 / Ngal / 腎障害 / バイオマーカー / 閉塞型睡眠時無呼吸 / 好中球ゼラチラーゼ結合性リポカリン / 血管内皮機能 / 睡眠時無呼吸症候群 / 間欠的低酸素 / 細胞実験 / NGAL / 気道上皮 / 好中球ゼラチラーゼ結合性リポカリン(NGAL) |
Outline of Final Research Achievements |
Obstructive sleep apnea (OSA) and a novel lipocalin, neutrophil gelatinase associated lipocalin (Ngal),have been reported to be closely linked with cardiovascular disease and loss of kidney function through chronic inflammation. However, the relationship between OSA and Ngal has never been investigated. In 102 patients, plasma Ngal levels were measured. Ngal levels were reevaluated after three months of treatment in 25 patients.The Ngal level correlated significantly with OSA severity as determined by the apnea hypopnea index and 4% oxygen desaturation index (ODI). Multiple regression analysis showed that the Ngal level was associated with 4%ODI independently of other clinical variables. The Ngal levels were not significantly changed after CPAP.Plasma Ngal levels were positively associated with the severity of OSA. However, it does not seem reasonable to use the Ngal level as a specific biomarker of OSA in clinical practice.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Association Between Endothelial Function (Assessed on Reactive Hyperemia Peripheral Arterial Tonometry) and Obstructive Sleep Apnea, Visceral Fat Accumulation, and Serum Adiponectin2015
Author(s)
Azuma M, Chihara Y, Yoshimura C, Murase K, Hamada S, Tachikawa R, Matsumoto T, Inouchi M, Tanizawa K, Handa T, Oga T, Mishima M, Chin K
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Journal Title
Circulation Journal
Volume: 79
Issue: 6
Pages: 1381-1389
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A urine biomarker for severe OSA patients: lipocaline-type prostaglandin D synthase.2013
Author(s)
Chihara Y, Chin K, Aritake K, Harada Y, Toyama Y, Murase K, Yoshimura C, Hitomi T, Oga T, Mishima M, Urade Y.
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Journal Title
Eur Respir J
Volume: in press
Issue: 6
Pages: 1563-1574
DOI
Related Report
Peer Reviewed
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[Journal Article] Association between plasma neutrophil gelatinase associated lipocalin level and obstructive sleep apnea or nocturnal intermittent hypoxia2013
Author(s)
Murase K, Mori K, Yoshimura C, Aihara K, Chihara Y, Azuma M, Harada Y, Toyama Y, Tanizawa K, Handa T, Hitomi T, Oga T, Mishima M, Chin K
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Journal Title
PLoS One
Volume: 8
Issue: 1
Pages: e54184-e54184
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Measurement of dyspnea in patients with obstructive sleep apnea2013
Author(s)
Aihara K, Oga T, Yoshimura C, Hitomi T, Chihara Y, Harada Y, Murase K, Toyama Y, Tanizawa K, Handa T, Tsuboi T, Mishima M, Chin K
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Journal Title
Sleep Breath
Volume: 17(2)
Issue: 2
Pages: 753-761
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationships of Decreased Lung Function with Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males2012
Author(s)
C Yoshimura, T Oga, K Chin, M Takegami, K Takahashi, K Sumi, T Nakamura, Y Nakayama-Ashida, I Minami, S Horita, Y Oka, T Wakamura, S Fukuhara, M Mishima, H Kadotani
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Journal Title
Internal Medicine
Volume: 51
Issue: 17
Pages: 2291-2297
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Presentation] Endothelial Dysfunction Evaluated By Reactive Hyperemia Peripheral Arterial Tonometry (RH-PAT) In Obstructive Sleep Apnea Patients2014
Author(s)
Masanori Azuma, Yuichi Chihara, Chikara Yoshimura, Toru Oga, Kiminobu Tanizawa, Morito Inouchi, Yoshiro Toyama, Kimihiko Murase, Satoshi Hamada, Ryo Tachikawa, Michiaki Mishima, Kazuo Chin
Organizer
American Thoracic Society International Conference
Place of Presentation
San Diego, California, USA
Year and Date
2014-05-16 – 2014-05-21
Related Report
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[Presentation] Comparison of the effects of different antihypertensive drugs in patients with obstructive sleep apnea and hypertension following CPAP therapy.2013
Author(s)
Yoshimura C, Oga T, Murase K, Moritsuchi Y, Hitomi T, Watanabe K, Inoue H, Mishima M, Tsuda T, Chin K.
Organizer
American thoracic society international conference.
Place of Presentation
Philadelphia, U.S.A.
Related Report
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