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Physiological study of the pathogenesis of akathisia with respect to periodic limb movement

Research Project

Project/Area Number 24621006
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field 睡眠科学
Research InstitutionShimane University

Principal Investigator

HORIGUCHI Jun  島根大学, 医学部, 教授 (90136317)

Co-Investigator(Kenkyū-buntansha) OKAZAKI Shihou  島根大学, 医学部, 助教 (20379671)
YASUDA Hideaki  島根大学, 医学部, 助教 (30379680)
MIYAOKA Tsuyoshi  島根大学, 医学部, 准教授 (50284047)
WAKE Rei  島根大学, 医学部, 講師 (60609262)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords周期性四肢運動 / 脊髄自動反射 / バビンスキー反射 / ワンテンベルグ反射 / アカシジア / ワルテンベルグ反射
Outline of Final Research Achievements

We investigated the recording of the periodic limb movements with the patients with akathisia using polysomnography and videotape recordings. As a result, we had 3 important new findings by our this research.
① No restriction of the daytime subject’s movement could be obtained using the PolymateⅡ.② Nocturnal sleep stages such as slight and deep non-REM sleep and REM sleep could be judged.③ And, the analizing time shortening and the precise accuracy could be taken using the videotape recording with myogram.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (37 results)

All 2014 2013 2012

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 8 results,  Acknowledgement Compliant: 7 results) Presentation (11 results) (of which Invited: 2 results) Book (10 results)

  • [Journal Article] Minocycline improves recognition memory and attenuates microglial activation in Gunn rat.a possible hyperbilirubinemia-induced animal model of schizophrenia.2014

    • Author(s)
      Liaury K, Miyaoka T, Tsumori T, Furuya M, Hashioka S, Wake R, Tsuchie K, Fukushima M, Limoa E, Tanra AJ, Horiguchi J
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 50 Pages: 184-190

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Evaluation of the difference-correction effect of the gamma camera systems used by easy Z-score Imaging System(eZIS)analysis.2014

    • Author(s)
      Yamamoto Y, Onoguchi M, Kawakami K, Haramoto M, Wake R, Horiguchi J, Kitagaki H
    • Journal Title

      Ann Nucl Med.

      Volume: 28(3) Pages: 263-275

    • NAID

      120005411684

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The relation between ADHD and ANS-CNS integration.2014

    • Author(s)
      Hayashida M, Miyaoka T, Horiguchi J
    • Journal Title

      Open Journal of Psychiatry

      Volume: 4 Pages: 39-42

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effects of aging on changes in regional cerebral blood flow in schizophrenia.2014

    • Author(s)
      Kawakami K, Wake R, Miyaoka T, Furuya M, Liaury K, Horiguchi J
    • Journal Title

      Neuropsychobiology

      Volume: 69(4) Pages: 202-209

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A decrease in N-acetylaspartate and an increse in myoinositol in the anterior cingulate gyrus are associated with behavioral and psychological symptoms in Alzheimer's disease.2014

    • Author(s)
      Shinno H, Inagaki T, Miyaoka T, Okazaki S, Kawamukai T, Utani E, Inami Y, Horiguchi J
    • Journal Title

      J Neurol Sci.

      Volume: 343(1-2) Pages: 233-234

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The effects of combine treatment of memantine and donepezil on Alzheimer's disease patients and its relationship with cerebral blood flow in the prefrontal area.2014

    • Author(s)
      Araki T, Wake R, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Liaury K, Hashioka S, Murotani K, Horiguchi J
    • Journal Title

      Int J Geriatr Psychiatry

      Volume: 29(9) Pages: 881-889

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Neuroleptics and microglial activation associated with neuropsychiatric disorders.2014

    • Author(s)
      Hashipka S, McGeer PL, Miyaoka T, Wake R, Horiguchi J
    • Journal Title

      Journal of Neurologcal Disorders & Stroke.

      Volume: 2(5) Pages: 1089-1095

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Yokukansan increases serum Brain-derived neurotrophic factor(BDNF) levels in Gunn rat.2014

    • Author(s)
      Furuya M, Miyaoka T, Hashioka S, Wake R, Tsuchie K, Horiguchi J
    • Journal Title

      Journal of Brain Science.

      Volume: 44 Pages: 34-41

    • NAID

      110009913042

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possibility of early withdrawal of benzodiazepine hypnotics by combination with ramelteon for the treatment of insomnia: A pilot study.2013

    • Author(s)
      Furuya M, Miyaoka T, Wake R, Nagahama M, Kawano K, Yamashita S, Ieda M, Ezoe S and Horiguchi J
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 11(1) Pages: 55-61

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yokukansan(TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: An open-label study.2013

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S and Horiguchi J
    • Journal Title

      Phytomedicine

      Volume: 20(7) Pages: 654-658

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of autonomic nervous system by salivary alpha-amylase level and heart rate variability in patients with schizophrenia.2013

    • Author(s)
      Ieda M, Miyaoka T, Wake R, Liaury K, Tsuchie K, Fukushima M, Araki T, Ezoe S, Inagaki T, Horiguchi J
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci.

      Volume: 10 Pages: 411-416

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yokukansan(TJ-54) for Irritability Associated with Pervasive Developmental Disorder in Children and Adolescents: A 12-Week Prospective,Open-Label Study.2013

    • Author(s)
      Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K and Horiguchi J
    • Journal Title

      JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY

      Volume: 23(5) Pages: 329-336

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Morphological features of microglial cells in the hippocampal dentate gyrus of Gunn rat: a possible schizophrenia animal model.2012

    • Author(s)
      Liaury K, Miyaoka T, Tsumori T, Furuya M, Wake R, Ieda M, Taki M, Ishihara K, A J Tanra,Horiguchi J
    • Journal Title

      Journal of Neuroinflammation

      Volume: 9 Pages: 56-56

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yokukansan(TJ-54) for treatment of very-late-onset Schizophrenia-like psychosis. An open- Label Study Authors.2012

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
    • Journal Title

      Phytomedicine

      Volume: 20(7) Pages: 654-8

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minocycline as adjunctive therapy for patients with unipolar psychotic depression: an open-label study.2012

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Taki M, Ishihara K, Araki T, Horiguchi J
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 37(2) Pages: 222-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Yokukansan(TJ-54) for Treatment of Pervasive Developmental Disorder Not Otherwise Specified and Asperger's Disorder:2012

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Inagaki T and Horiguchi J
    • Journal Title

      BMC Psychiatry

      Volume: 12(1) Pages: 215-215

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Efficacy and safety of Sansoninto in Insomnia with Psychiatric Disorder. An Open-Label Study.2014

    • Author(s)
      Miyaoka T, Kawano K, Furuya M, Wake R, Hashioka S, Liaury K, Limoa E, Tsuchie K, Araki T, Horiguchi J
    • Organizer
      第19回日本神経精神医学会. 第14回ICGP合同会議.
    • Place of Presentation
      つくば市(つくば国際会議場)
    • Year and Date
      2014-10-01 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] The long-term effects of combine treatment of memantine and donepezil on Alzheimer’s Disease patients: 72 weeks study2014

    • Author(s)
      Wake R, Araki T, Miyaoka T, Kawakami K, Nagahama M, Furuya M, Limoa E, Hashioka S, Horiguchi J
    • Organizer
      第19回日本神経精神医学会. 第14回ICGP合同会議.
    • Place of Presentation
      つくば市(つくば国際会議場)
    • Year and Date
      2014-10-01 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] The histone decetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocte neurotoxicity2014

    • Author(s)
      Hashioka S, Kleger A, Miyaoka T, Wake R, Horiguchi J, LMcGeer P
    • Organizer
      第19回日本神経精神医学会. 第14回ICGP合同会議.
    • Place of Presentation
      つくば市(つくば国際会議場)
    • Year and Date
      2014-10-01 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 故き温ね、新しきを創る~島根の抑肝散研究の歴史と近未来~.2014

    • Author(s)
      堀口淳
    • Organizer
      第36回日本生物学的精神医学会.
    • Place of Presentation
      奈良市(奈良県新公会堂)
    • Year and Date
      2014-09-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Yokukansan(TJ-54) for Irritability Associated with Pervasive Developmental Disorder in Children and Adolescents A 12-week Prospective, Open-label Study.2013

    • Author(s)
      Wake R, Miyaoka T, Inagaki T, Furuya M, Ieda M, Liaury K, Kishi K, Horiguchi J
    • Organizer
      The 7th Annual Scientific Meeting Hong Kong Society
    • Place of Presentation
      (Hong Kong) Eaton
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Efficacy and Safety of Yokukansan(TJ-54) for Treatment-Resistant Schizophrenia:A Randmized,Multi-centre,Double blind,Placebo-controlled Trial.2013

    • Author(s)
      Miyaoka T, Furuya M, Horiguchi J, Wake R, Hashioka S, Toyama M, Daimon T, Mori N, Minabe Y, Iyo M, Ueno S, Ezoe S, Hosyino S, Seno H
    • Organizer
      Society of Biological Psychiatry 68th Annual Meeting.
    • Place of Presentation
      (California San Francisco) Hilton Union Square
    • Related Report
      2013 Research-status Report
  • [Presentation] Minocycline improve prepulse inhibition(PPI) deficits through inhibition of microglial activation in the dentate gyrus of Gunn rat: a neuroinflammatory animal model of schizophrenia.2013

    • Author(s)
      Liaury K, Miyaoka T, Tsumori T, Furuya M, Wake R, Ieda M, Tsuchie K, Fukushima M, Tanra A, Horiguchi J
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      京都市(国立京都国際会館)
    • Related Report
      2013 Research-status Report
  • [Presentation] Yokukansan(TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: an open-label study.2013

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
    • Organizer
      The3rd Asian Congress of Schizophrenia Research.
    • Place of Presentation
      Indonesia(Bali)
    • Related Report
      2012 Research-status Report
  • [Presentation] The effects of minocycline on the CD 11b expression of the microglial cells in the dentate gyrus of Gunn rat: a possible animal model of schizophrenia.2012

    • Author(s)
      Liaury K, Miyaoka T, Tsumori T, Furuya M, Wake R, Ieda M, Tsuchie K, Fukushima M, Ishihara K, Tanra A, Horiguchi J
    • Organizer
      The 35th Annual Meeting of the Japan Neuroscience Society.
    • Place of Presentation
      Nagoya Congress Center
    • Related Report
      2012 Research-status Report
  • [Presentation] 仁王とレストレスレッグズ2012

    • Author(s)
      堀口淳
    • Organizer
      日本睡眠学会第37回定期学術集会
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] Yokukansan(TJ-54) for treatment of very-late-onset schizophrenia-like psychosis: an open-label study.2012

    • Author(s)
      Miyaoka T, Wake R, Furuya M, Liaury K, Ieda M, Kawakami K, Tsuchie K, Fukushima M, Ishihara K, Araki T, Hashioka S, Horiguchi J
    • Organizer
      12th Annual Meeting of the International College of Geriatric Psychoneuropharmacology
    • Place of Presentation
      Spain(Sevilia)
    • Related Report
      2012 Research-status Report
  • [Book] 統合失調症. ガイドライン外来診療2014 今日の診療のために.2014

    • Author(s)
      堀口淳
    • Total Pages
      4
    • Publisher
      日経メディカル開発
    • Related Report
      2014 Annual Research Report
  • [Book] 漢方薬の可能性~日々の臨床実践からの実態~. 統合失調ひろば2014

    • Author(s)
      堀口淳
    • Total Pages
      4
    • Publisher
      こころの科学
    • Related Report
      2014 Annual Research Report
  • [Book] 抑肝散2014

    • Author(s)
      堀口淳
    • Total Pages
      12
    • Publisher
      臨牀と研究
    • Related Report
      2014 Annual Research Report
  • [Book] 今日の治療指針 2013年版 私はこう治療している 統合失調症(初回エピソード) P874-875 (一部執筆)2013

    • Author(s)
      堀口淳
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Book] 別冊・医学のあゆみ 漢方医学の進歩と最新エビデンス 認知症およびその周辺症状の漢方治療:最新のエビデンス~われら臨床医のこの一手,抑肝散,認知症以外も含めて~ P71-79 (一部執筆)2013

    • Author(s)
      堀口淳、松本貴久、坪内健
    • Total Pages
      9
    • Publisher
      医歯薬出版
    • Related Report
      2013 Research-status Report
  • [Book] 医療・看護・介護のための睡眠検定ハンドブック 1.高齢者の不眠症 2.睡眠時随伴症 3.睡眠関連運動障害 P185-196 (一部執筆)2013

    • Author(s)
      河野公範、堀口淳
    • Total Pages
      12
    • Publisher
      全日本病院出版会
    • Related Report
      2013 Research-status Report
  • [Book] 今日の治療指針 統合失調症 P874-875 (分担執筆)2013

    • Author(s)
      堀口 淳
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 標準精神医学 器質性精神障害 P387-398 (分担執筆)2012

    • Author(s)
      堀口 淳
    • Total Pages
      12
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] 睡眠医学アトラス検査と臨床 レストレスレッグス症候群と周期性四肢運動異常症 P67-74 (共著・分担執筆)2012

    • Author(s)
      水野 創一、坪内 健、堀口 淳
    • Total Pages
      8
    • Publisher
      真興交易医書出版部
    • Related Report
      2012 Research-status Report
  • [Book] 脳とこころのプライマリケア5意識と睡眠 身体疾患による不眠 P586-589 (共著・分担執筆)2012

    • Author(s)
      河野 公範、堀口 淳
    • Total Pages
      4
    • Publisher
      シナジー
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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