| Project/Area Number |
24621009
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
睡眠科学
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYAMOTO Tomoyuki 獨協医科大学越谷病院, 神経内科, 教授 (40296174)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | レム睡眠行動異常症 / 黒質線条体ドパミン神経 / FMT-PET / 経年変化 / パーキンソン病 / レビー小体関連疾患 / 特発性レム睡眠行動異常症 / 黒質線条体ドパミン神経系 / 経年的変化 / 縦断的研究 / 睡眠関連疾患 / 脳神経疾患 / 睡眠医学 / 内科 / 画像診断 |
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| Outline of Final Research Achievements |
In recent studies, Some REM sleep behavior disorder (RBD) patients reported an increased risk to develop Parkinson's disease (PD). We prospectively assessed a nigrostriatal dopaminergic function using by FMT-PET in patients with idiopathic RBD (IRBD) and compared the finding with healthy controls at baseline and after 1.3 to 5.3 years. At baseline, there are a lot of individual variation in FMT uptake in putamen in IRBD. IRBD patients, who developed PD in the follow up period, reduced putaminal FMT uptake at baseline. However, in this study, reduction rate of putaminal FMT uptake was not associated with constipation, olfactory dysfunction or impaired color discrimination. Further prospective follow up study of this RBD cohort is needed to clarify predictors of pathological neurodegenerative process of nigrostriatal dopaminergic neurons and be useful in studies of potential disease-modifying therapy in these patients.
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