Effect of blocking 450-500nm light by special goggle on performance and autonomic function during night shift simulation.

• Project/Area Number: 24621010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Kitasato University
• Principal Investigator: TAGAYA Hirokuni 北里大学, 医療衛生学部, 教授 (50342928)
• Co-Investigator(Kenkyū-buntansha): TANAKA Katsutoshi 北里大学, 大学院医療系研究科, 教授 (30365176) ; ISHIKAWA Hitoshi 北里大学, 医療衛生学部, 教授 (80265701)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 交代勤務 / 遂行能力 / 環境光 / 概日リズム / 睡眠生理学 / 認知機能 / 自律神経機能 / 24時間社会 / 事故防止 / 光環境 / 睡眠学 / メラトニン / メラノプシン

Outline of Final Research Achievements

Blue to green (450-500nm) light shifts circadian phase and induces alertness. We developed special goggle blocking this band 95% (blue-light blocking goggle). Twenty healthy young volunteers were participated night shift sessions wearing whether a blue-blocking goggle or a placebo goggle in double blind randomized manner under white bright light (>1000 lux). Performance tests (PVT and DSST) and evaluation of autonomic function by heart rate variability were performed every 2 hours during a night session, and recovery sleep following 24 hour period was evaluated by actigram. Performance indices were declined and sympathetic activity was increased toward morning. Performances during the last session was improved by the blue-light blocking goggle. Slight color impairment and male were deteriorating factor of performance and enhancing factor of sympathetic activity.

Research Products

• [Journal Article] Cognitive dysfunction in patients with very mild Alzheimer’s disease and amnestic mild cognitive impairment showing hemispheric asymmetries of hypometabolism on 18F-FDG PET. (2015)
  • Author(s): Murayama N, Ota K, Kasanuki K, Kondo D, Fujishiro H, Fukase Y, Tagaya H, Sato K, Isek E.
  • Journal Title: Geriat Psychiatr. Volume: 30 Issue: 1 Pages: 4287-4287
  • DOI: 10.1002/gps.4287
  • Peer Reviewed / Open Access
• [Journal Article] Does neurocognitive function affect cognitive bias toward an emotional stimulus? Association between general attentional ability and attentional bias toward threat. (2014)
  • Author(s): Hakamata Y, Matui M, Tagaya H.
  • Journal Title: Frontier Psychol. Volume: 5 Pages: 881-881
  • DOI: 10.3389/fpsyg.2014.00881
  • Peer Reviewed / Open Access
• [Journal Article] EEG abnormalities among "normal" applicants for phase I clinical trials of an agent that could possibly act on the central nervous system. (2014)
  • Author(s): Saito M, Tagaya H, Ohshima A, Kumagai Y, Miyaoka H.
  • Journal Title: Kitasato Med J. Volume: 44 Pages: 189-194
  • Peer Reviewed
• [Journal Article] 睡眠障害. (2014)
  • Author(s): 田ヶ谷浩邦, 村山憲男, 袴田優子.
  • Journal Title: 日本臨牀 Volume: 72 Pages: 739-743
• [Journal Article] 睡眠呼吸障害と社会的問題. (2014)
  • Author(s): 田ヶ谷浩邦, 村山憲男, 袴田優子
  • Journal Title: Johns Volume: 30 Pages: 507-510
• [Journal Article] Intelligence or years of education: which is better correlated with memory function in normal elderly Japanese subjects? (2013)
  • Author(s): Murayama N, Iseki E, Tagaya H, Ota K, Kasanuki K, Fujishiro H, Arai H, Sato K
  • Journal Title: Psychogeriatrics Volume: 13 Pages: 9-16
  • Peer Reviewed
• [Journal Article] Neuropsychological Detection of the Early Stage of Amnestic Mild Cognitive Impairment without Objective Memory Impairment (2013)
  • Author(s): Murayama N, Tagaya H, Ota K, Fujishiro H, Manabe Y, Sato K, Isek E.
  • Journal Title: Dementia and geriatric cognitive disorders Volume: 35 Pages: 98-105
  • Peer Reviewed
• [Journal Article] Higher cortisol levels at diurnal trough predict greater attentional bias towards threat in healthy young adults (2013)
  • Author(s): Hakamata Y, Izawa S, Sato E, Komi S, Murayama N, Moriguchi Y, Hanakawa T, Inoue Y, Tagaya H
  • Journal Title: Journal of affective disorders Volume: 151 Pages: 775-779
• [Journal Article] 瞳孔とメラノプシンによる光受容 (2013)
  • Author(s): 石川均
  • Journal Title: 日本眼科学会雑誌(J Jpn Ophthalmol Soc) Volume: 117 Pages: 246-269
  • NAID: 10031155926
  • Peer Reviewed
• [Presentation] 超短時間型睡眠薬による急性徐波睡眠増強は健常若年男子の耐糖能には影響しなかったが、イ ンスリン分泌能は徐波睡眠量と正の相関を示した. (2014)
  • Author(s): 田ヶ谷浩邦, 熊谷雄治, 黒山政一, 村山憲男, 袴田優子.
  • Organizer: 日本睡眠学会第39回定期学術集会
  • Place of Presentation: あわぎんホール（徳島県徳島市）
  • Year and Date: 2014-07-03
• [Presentation] 抑肝散服用により生じる低カリウム血症の発現頻度と発現時期の後方視的調査. (2014)
  • Author(s): 本間雅士, 瀬川千聖, 黒田ちか江, 平山武司, 黒山政一, 長島和明, 大石智, 西山和利, 田ヶ谷浩邦, 宮岡等.
  • Organizer: 第110回日本精神神経学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-27
• [Presentation] 北里大学東病院における睡眠薬及び抗不安薬の処方実態. (2014)
  • Author(s): 黒田ちか江, 斉藤大樹, 本間雅士, 飛田夕紀, 平山武司, 黒山政一, 宮地伸吾, 大石智, 田ヶ谷浩邦, 宮岡等.
  • Organizer: 第110回日本精神神経学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-06-27
• [Presentation] 軽度認知障害やアルツハイマー病における脳等代謝量の非対称性と認知機能の関係. (2014)
  • Author(s): 村山憲男, 井関栄三, 太田一実, 笠貫浩史, 藤枝弘樹, 田ヶ谷浩邦, 佐藤潔.
  • Organizer: 第29回日本老年精神医学会
  • Place of Presentation: 東京教育会館一ツ橋ホール（東京都千代田区）
  • Year and Date: 2014-06-13
• [Presentation] Glucose tolerance were not affected by acute sleep enhancement by ultra-short acting hypnotics in healthy young males (2013)
  • Author(s): Tagaya H, Kumagai Y, Kuroyama M, Wakisaka M, Sato M
  • Organizer: sleep2013
  • Place of Presentation: Baltimore Convention Center（アメリカ国ボルチモア）
• [Presentation] 超短時間型BZ系およびnon-BZ系睡眠薬服用によるPVTへの影響は、服用12時間後には消失したが、DSSTスコア低下は残存していた (2013)
  • Author(s): 田ヶ谷浩邦, 熊谷雄治, 黒山政一, 袴田優子, 村山憲男
  • Organizer: 日本睡眠学会第38回定期学術集会
  • Place of Presentation: 秋田キャッスルホテル（秋田県秋田市）
• [Presentation] 脳糖代謝量に左右差がある軽度認知障害と初期アルツハイマー病の記憶機能の特徴 (2013)
  • Author(s): 村山憲男, 井関栄三, 田ヶ谷浩邦, 太田一実, 笠貫浩史, 藤城弘樹, 佐藤潔, 新井平伊
  • Organizer: 第28回日本老年精神医学会
  • Place of Presentation: 大阪国際会議場（大阪市北区）
• [Presentation] 睡眠・精神とメラノプシン (2013)
  • Author(s): 田ヶ谷浩邦
  • Organizer: 第49回日本眼光学学会総会
  • Place of Presentation: ウェスティン都ホテル京都（京都市東山区））
  • Invited
• [Presentation] 瞳孔動揺の日内変動と自然光との関連性
  • Author(s): 浅川賢、石川均、田ヶ谷浩邦、清水公也
  • Organizer: 第50回神経眼科学会
  • Place of Presentation: 京都
• [Book] 精神科医×薬剤師 クロストークから読み解く精神科薬物療法. (2014)
  • Author(s): 田ヶ谷浩邦, 椎崇
  • Total Pages: 324
  • Publisher: 南山堂
• [Book] DSM-5を読み解く3 双極性障害および関連障害群，抑うつ障害群，睡眠-覚醒障害群 (2014)
  • Author(s): 田ヶ谷浩邦, 袴田優子, 村山憲男
  • Total Pages: 298
  • Publisher: 中山書店