Molecular mechanism underlying disturbed circadian rhythms in sleep disorder
Project/Area Number |
24621015
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
睡眠科学
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
HIDA Akiko 独立行政法人国立精神・神経医療研究センター, 精神保健研究所・精神生理研究部, 室長 (20333354)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | 生物時計 / 睡眠 / 生体リズム |
Outline of Final Research Achievements |
Circadian clocks regulate daily behavioral and physiological rhythms. These rhythms are generated by a self-sustained clock system. The circadian clock system involves transcription-translation negative feedback loops of multiple clock genes. Circadian rhythm sleep disorders (CRSDs) are defined by persistent or recurrent disturbed sleep-wake cycles and are thought to result from the impairment of the circadian clock system. Clock gene expression was measured in fibroblasts derived from healthy subjects and rhythmic expression was observed in the cells (in vitro rhythm). The period length of in vitro rhythm was correlated with diurnal preference and preferred sleep timing. Evaluating in vitro rhythm may therefore be an appropriate method to assess an individual's circadian clock phenotype. In vitro rhythms were measured in fibroblasts derived from patients with CRSDs and the circadian characteristics of in vitro rhythms were compared to the phenotypes of the patients.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Screening of Clock Gene Polymorphisms Demonstrates Association of a PER3 Polymorphism with Morningness-Eveningness Preference and Circadian Rhythm Sleep Disorder2014
Author(s)
Hida A, Kitamura S, Katayose Y, Kato M, Ono H, Kadotani H, Uchiyama M, Ebisawa T, Inoue Y, Kamei Y, Okawa M, Takahashi K, Mishima K
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Journal Title
Scientific Reports
Volume: 4(6309)
Issue: 1
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Association of a PER3 Polymorphism with Morningness–Eveningness Preference and Circadian Rhythm Sleep Disorder2014
Author(s)
Hida A, Kitamura S, Katayose Y, Kato M, Ono H, Kadotani H, Uchiyama M, Ebisawa T, Inoue Y, Kamei Y, Okawa M, Takahashi K, Mishima K
Organizer
第21回日本時間生物学会学術大会
Place of Presentation
福岡 九州大学医学部百年講堂
Year and Date
2014-11-07 – 2014-11-09
Related Report
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[Presentation] 概日リズム睡眠障害の発症機序:末梢時計機能の評価2014
Author(s)
肥田昌子, 北村真吾, 中崎恭子, 元村祐貴, 綾部直子, 加藤美恵, 小野浩子, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 亀井雄一, 三島和夫
Organizer
日本睡眠学会第39回定期学術集会
Place of Presentation
徳島 あわぎんホール
Year and Date
2014-07-03 – 2014-07-04
Related Report
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[Presentation] 概日リズム睡眠障害患者の生物時計機能障害2013
Author(s)
肥田昌子, 北村真吾, 片寄泰子, 中﨑恭子, 元村祐貴, 大場健太郎, 野崎健太郎, 加藤美恵, 小野浩子, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 亀井雄一, 三島和夫
Organizer
日本睡眠学会第38回定期学術集会
Place of Presentation
秋田 秋田キャッスルホテル
Related Report
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[Presentation] 末梢時計リズムは個人の睡眠特性・生物時計機能を反映する2012
Author(s)
肥田昌子, 北村真吾, 大澤要介, 片寄泰子, 野崎健太郎, 榎本みのり, 有竹清夏, 樋口重和, 加藤美恵, 亀井雄一, 池田正明, 三島和夫
Organizer
第19回日本時間生物学会学術大会
Place of Presentation
北海道大学学術交流会館 北海道
Related Report
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