| Project/Area Number |
24650141
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cognitive science
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
KODAMA Tohru 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 副参事研究員 (20195746)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masataka 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, シニア研究員 (50092383)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | Dopamine / Frontal cortex / default activity / デフォルト活動 / 前頭葉 / ニホンザル / ドーパミン |
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| Research Abstract |
Two monkeys were trained in a WM (spatial delayed alternation) task. We examined dopamine release while the monkey was (1) performing the WM task with a liquid reward (WM task period) and (2) sitting quietly without task performance and without reward (REST period). During the WM task period, we observed a significant decrease in dopamine release compared with during the REST period in the medial prefrontal cortex (PFC). Neuroimaging studies have indicated activations of the dorsolateral PFC in relation to WM task performance, and increased dopamine release in the dorsolateral PFC is considered to play essential roles in WM task performance. In contrast, in the medial PFC, we observed increases in both the rCBF and dopamine release during REST as compared with WM task period. Our results suggest that cognitive operations associated with default-mode brain activity in the medial PFC may be supported by the increased dopamine release.
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