Clarification of Cancer Attractor of Cancer Epithelial Mesenchymal Transition
| Project/Area Number |
24650154
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Hiroshi 東京医科歯科大学, 難治疾患研究所, 教授 (60155158)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 上皮間葉転換 / 遺伝子ネットワーク / がん転移 / 臨界状態 / 幹細胞状態 / 遺伝子発現プロファイル / Waddington地形 / ARACNe / 生体生命情報学 / システム生物学 / 癌アトラクター |
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| Outline of Final Research Achievements |
In order to understand the mechanism of EMT, we created the state space covering all the possible gene expression patterns and introduced a quasi potential distribution showing the stability of each state in this state space. Then we depicted the trajectory of state change during cancer EMT. We found that EMT exhibits 3 stages, where intermediate stage is thought to be a critical transient state or the stem cell state. We estimated the structural change of gene network during EMT, by applying the inference algorithm to gene expression profiles during EMT, and found structural change of gene network reflected the three stage transition of cancer EMT process.
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Report
(4 results)
Research Products
(3 results)
