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Clarification of Cancer Attractor of Cancer Epithelial Mesenchymal Transition

Research Project

Project/Area Number 24650154
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TANAKA Hiroshi  東京医科歯科大学, 難治疾患研究所, 教授 (60155158)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords上皮間葉転換 / 遺伝子ネットワーク / がん転移 / 臨界状態 / 幹細胞状態 / 遺伝子発現プロファイル / Waddington地形 / ARACNe / 生体生命情報学 / システム生物学 / 癌アトラクター
Outline of Final Research Achievements

In order to understand the mechanism of EMT, we created the state space covering all the possible gene expression patterns and introduced a quasi potential distribution showing the stability of each state in this state space. Then we depicted the trajectory of state change during cancer EMT. We found that EMT exhibits 3 stages, where intermediate stage is thought to be a critical transient state or the stem cell state. We estimated the structural change of gene network during EMT, by applying the inference algorithm to gene expression profiles during EMT, and found structural change of gene network reflected the three stage transition of cancer EMT process.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinome2014

    • Author(s)
      Eslami A., Miyagushi K.,Mogushi K., Watanabe H., Okada N., Shibuya H., Mizushima H., Miura M., Tanaka H.
    • Journal Title

      British Journal of Cancer

      Volume: 1 Issue: 2 Pages: 1-7

    • DOI

      10.1038/bjc.2014.590

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 細胞の分化・誘導に関わる発現ポテンシャル解析2013

    • Author(s)
      荻島創一, 田中博
    • Organizer
      次世代シーケンス現場の会第3回大会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] "Expression trajectories" of reprogramming and differentiation on expression potential field.2012

    • Author(s)
      Tadashi Miyamoto, Soichi Ogishima, Jun Nakaya, Hiroshi Tanaka
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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