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Construction of a programmable and dynamical reaction field inspired by biosynthesis

Research Project

Project/Area Number 24650157
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Bioinformatics/Life informatics
Research InstitutionTokyo Institute of Technology

Principal Investigator

Komiya Ken  東京工業大学, 総合理工学研究科(研究院), 助教 (20396790)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDNAコンピュータ / DNAナノテクノロジー / ナノマシン / ナノ反応場 / ニッキング酵素 / DNAウォーカ / DNAzyme / DNAコンピュータ / 生体生命情報学 / 知能ロボティックス / 高分子合成
Outline of Final Research Achievements

In this research project, construction of a dynamical reaction field at a nano-meter scale was investigated by taking advantage of an autonomous walking device, consisting of a set of DNA strands and an enzyme, for achieving autonomous implementation of a multi-step polymerization reaction. We revealed the optimal length of DNA sequences and the appropriate enzymes that could improve the walking performance of the device, via absorbance measurement, fluorescence measurement and electrophoresis. In addition, we revealed the use of DNAzyme is preferable for improving the efficiency and flexibility in synthesis reaction. Currently, construction of a programmable and dynamical reaction field at a nano-meter scale is under further investigation by integrating the obtained knowledge.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2014 2013 2012 Other

All Presentation (21 results) (of which Invited: 8 results) Remarks (2 results)

  • [Presentation] Implementation of in vitro intelligence for real-time operation of molecular robots2014

    • Author(s)
      K. Komiya
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌市
    • Year and Date
      2014-09-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] VEAM : 研究者と市民をつなぐ科学知識の視覚化2013

    • Author(s)
      小宮健
    • Organizer
      「細胞を創る」研究会6.0
    • Place of Presentation
      鶴岡市
    • Year and Date
      2013-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 血小板摸倣システムに向けたDNA架橋ハイドロゲルの作成2013

    • Author(s)
      北島貴司, 小宮健, 早川雅之, 森田雅宗, 瀧ノ上正浩, 山村雅幸
    • Organizer
      「細胞を創る」研究会6.0
    • Place of Presentation
      鶴岡市
    • Year and Date
      2013-11-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Introduction of DNA nanodevices into a hydrogel for achieving its stimuli- responsive behavior2013

    • Author(s)
      T. Kitajima, K. Komiya, M. Hayakawa, M. Takinoue and M. Yamamura
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2013-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Implementation of in vitro intelligence for controlling molecular robots2013

    • Author(s)
      K. Komiya
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2013-10-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Construction of a DNA-based stimuli- responsive microhydrogel2013

    • Author(s)
      T. Kitajima, K. Komiya, M. Hayakawa, M. Takinoue and M. Yamamura
    • Organizer
      Nineteenth International Meeting on DNA Computing and Molecular Programming (DNA19)
    • Place of Presentation
      Tempe
    • Related Report
      2013 Final Research Report
  • [Presentation] Construction of a DNA-based stimuli-responsive microhydrogel2013

    • Author(s)
      Takashi Kitajima, Ken Komiya, Masayuki Hayakawa, Masahiro Takinoue and Masayuki Yamamura
    • Organizer
      The Nineteenth International Meeting on DNA Computing and Molecular Programming (DNA19)
    • Place of Presentation
      Arizona State University, Tempe, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分子ロボットの知能2012

    • Author(s)
      小宮健
    • Organizer
      システム・情報部門学術講演会2012 (SSI2012)
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-11-23
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 分子ロボットの実現に向けたDNA論理ゲートの現状と課題2012

    • Author(s)
      小宮健
    • Organizer
      人工知能学会合同研究会第51回分子生物情報研究会(SIG-MBI)
    • Place of Presentation
      横浜市
    • Year and Date
      2012-11-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Construction of a nucleic-acid- responsive DNA synthesis system for diagnostic DNA-based computing2012

    • Author(s)
      K. Komiya, A. Kobayashi and M. Yamamura
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Biomolecular Rocket2012

    • Author(s)
      星健介, 厚美佑輔, 齋藤健, 山下仁義, 松戸里紗, 番匠康雄, 小長谷明彦, 木賀大介, 山村雅幸, 小宮健, 瀧ノ上正浩
    • Organizer
      細胞を創る」研究会5.0
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report
  • [Presentation] 加法的な視覚化による科学的知識への関心の喚起2012

    • Author(s)
      小宮健
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      横浜市
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Biomolecular Rocket2012

    • Author(s)
      星健介,厚美佑輔,齋藤健,山下仁義,松戸里紗,番匠康雄,小長谷明彦,木賀大介,山村雅幸,小宮健,瀧ノ上正浩
    • Organizer
      「細胞を創る」研究会5.0
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] Implementation of in vitro intelligence for controlling molecular robots

    • Author(s)
      Ken Komiya
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都国際会議場(京都市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Introduction of DNA nanodevices into a hydrogel for achieving its stimuli-responsive behavior

    • Author(s)
      Takashi Kitajima, Ken Komiya, Masayuki Hayakawa, Masahiro Takinoue and Masayuki Yamamura
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都国際会議場(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血小板摸倣システムに向けたDNA架橋ハイドロゲルの作成

    • Author(s)
      北島貴司,小宮健,早川雅之,森田雅宗,瀧ノ上正浩,山村雅幸
    • Organizer
      「細胞を創る」研究会6.0
    • Place of Presentation
      慶應義塾大学鶴岡タウンキャンパス(鶴岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] VEAM: 研究者と市民をつなぐ科学知識の視覚化

    • Author(s)
      血小板摸倣システムに向けたDNA架橋ハイドロゲルの作成
    • Organizer
      「細胞を創る」研究会6.0
    • Place of Presentation
      慶應義塾大学鶴岡タウンキャンパス(鶴岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implementation of in vitro intelligence for real-time operation of molecular robots

    • Author(s)
      Ken Komiya
    • Organizer
      第52回日本生物物理学会年会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 分子ロボットの知能

    • Author(s)
      小宮健
    • Organizer
      計測自動制御学会 システム・情報部門 学術講演会 2012
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 分子ロボットの実現に向けたDNA論理ゲートの現状と課題

    • Author(s)
      小宮健
    • Organizer
      人工知能学会合同研究会 第51回分子生物情報研究会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Construction of a nucleic-acid-responsive DNA synthesis system for diagnostic DNA-based computing

    • Author(s)
      Ken Komiya, Asako Kobayashi and Masayuki Yamamura
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://bio-inspired.chemistry.jpn.com/

    • Related Report
      2013 Final Research Report
  • [Remarks] YALIMAS

    • URL

      http://bio-inspired.chemistry.jpn.com/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2023-01-30  

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