| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Circadian clocks control physiological and behavioral rhythms. In mice, nursing behavior show a clear diurnal rhythm that is governed by the circadian clock. Importantly, maternal care influences the development of emotional behavior of the offspring. We found that circadian clock-disrupted mutant mice (Clock mutant mice) display the altered daily pattern of nursing behavior. Wild-type mice fostered by Clock mutant mice exhibit increased anxiety-related behavior. This is coupled with reduced levels of brain serotonin at postnatal day 14, a critical regulator for maturation of normal anxiety-modulating circuits during the postnatal development. Thus, disruption of the circadian clock in mothers has an adverse impact on establishing normal anxiety levels, which may suggest the increased risk of anxiety disorders in offspring of mothers with diurnal rhythm disturbance.
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