Diagnosis and Treatment of Cognitive Deficit Caused by Radiation in Patients with Brain Tumors
Project/Area Number |
24650168
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Neuroscience in general
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Research Institution | University of the Ryukyus |
Principal Investigator |
ISHIUCHI SHOGO 琉球大学, 医学(系)研究科(研究院), 教授 (10312878)
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Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Daisuke 琉球大学, その他部局等, その他 (00112160)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 放射線障害 / 認知機能 / 海馬 / 神経新生 / 高次脳機能 / 認知科学 / 放射線治療 / 神経幹細胞 / 神経前駆細胞 / 認知能 |
Outline of Final Research Achievements |
Radiotherapy is an important treatment option for central nervous system malignancies, however, cranial radiation induces hippocampal dysfunction and white matter injury, which concomitantly induced higher cognitive dysfunction,resulted in reduced quality of life (QOL) in the patients of brain disorders. We found that impaired hippocampal network of pattern separation ability detected by functional magnetic resonance imaging, and white matter damage by diffusion tensor imaging was main cause of higher cognitive dysfunction in patients with radiotherapy as well as animal models. Establishment of the therapy to facilitate the restration of hippocampal function , white matter integrity may bring improvement of executive function in the patients receiving cranial radiation.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Caffeine Contained in a Cup of Coffee Enhances Microvascular Endothelial Function in Healthy Subjects.2015
Author(s)
Noguchi K, Matsuzaki T, Sakanashi M, Hamadate N, Uchida T, Kina-Tanada M, Kubota H, Nakasone J, Sakanashi M, Ueda S, Masuzaki H, Ishiuchi S, Ohya Y, Tsutsui M
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Journal Title
J Pharmacol Sci
Volume: 127
Issue: 2
Pages: 217-222
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] γ-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice.2015
Author(s)
Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H
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Journal Title
Endocrinology
Volume: 156
Issue: 4
Pages: 1242-1250
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.2014
Author(s)
Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M.
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Journal Title
J Mol Cell Cardiol.
Volume: 77
Pages: 29-41
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 3次元CG支援による脳神経外科2014
Author(s)
宮城智央, 小林繁貴, 金城雄生, 長嶺英樹, 外間洋平, 西村正彦, 田村貴光, 菅原健一, 渡邉孝, 石内勝吾
Organizer
第73回日本脳神経外科学会学術総会
Place of Presentation
グランドプリンスホテル新高輪
Year and Date
2014-10-10
Related Report
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