Research Project
Grant-in-Aid for Challenging Exploratory Research
In this study, we tried to understand molecular mechanisms by which memory is updated. To do this, we examined roles of proteasome-dependent protein degradation in process such as memory reconsolidation and extinction, both of which are models of updating memory, using several memory tasks in mice. We found that proteasome-dependent protein degradation is activated when retrieved memory is reconsolidated, enhanced or extinguished. In contrast, this protein degradation was not activated when memory is initially consolidated. Furthermore, the inhibition of proteasome-dependent degradation using drugs blocked destabilization, enhancement and extinction of retrieved memory. Taken together, our observations suggest that activation of proteasome-dependent protein degradation is required for update (modification) of existing memory. It is possible that proteasome-dependent protein degradation is an useful molecular marker of updating memory.
All 2014 2013 2012 Other
All Journal Article (14 results) (of which Peer Reviewed: 13 results, Open Access: 1 results) Presentation (64 results) (of which Invited: 12 results) Book (5 results)
Brain Research Bulletin
Volume: (in press)
Hippocampus
Volume: (in press) Issue: 7 Pages: 784-93
10.1002/hipo.22270
Brain Research Bulletin.
Volume: 印刷中
Current Molecular Medicine.
Hippocampus.
Mol. Brain
Volume: 6 Issue: 1 Pages: 37-37
10.1186/1756-6606-6-37
化学と生物
Volume: 51 Pages: 81-89
10031146883
分子精神医学
Volume: 13 Pages: 307-309
Mol Brain
Volume: 6 Pages: 37-37
Mol. Pain
Volume: 8 Pages: 90-90
10.1186/1744-8069-8-90
Molecular Brain.
Volume: 5 Issue: 1 Pages: 27-27
10.1186/1756-6606-5-27
Experimental Neurobiology
Volume: 21 Issue: 4 Pages: 136-140
10.5607/en.2012.21.4.136
Mol Brain.
Volume: 5(On line) Issue: 1 Pages: 8-8
10.1186/1756-6606-5-8
eLife
