Roles of proteasome-dependent protein degradation in updating memory
| Project/Area Number |
24650172
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
KIDA Satoshi 東京農業大学, 応用生物科学部, 教授 (80301547)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経科学 / 脳・神経 / 記憶再固定化 / 記憶消去 / 記憶想起 / 記憶アップデート / タンパク質分解 / 記憶固定化 |
|---|
| Research Abstract |
In this study, we tried to understand molecular mechanisms by which memory is updated. To do this, we examined roles of proteasome-dependent protein degradation in process such as memory reconsolidation and extinction, both of which are models of updating memory, using several memory tasks in mice. We found that proteasome-dependent protein degradation is activated when retrieved memory is reconsolidated, enhanced or extinguished. In contrast, this protein degradation was not activated when memory is initially consolidated. Furthermore, the inhibition of proteasome-dependent degradation using drugs blocked destabilization, enhancement and extinction of retrieved memory. Taken together, our observations suggest that activation of proteasome-dependent protein degradation is required for update (modification) of existing memory. It is possible that proteasome-dependent protein degradation is an useful molecular marker of updating memory.
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Report
(3 results)
Research Products
(83 results)
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[Journal Article] Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine : implications for enhanced hippocampal adult neurogenesis2014
Author(s)
Ishikawa, R., Kim, R., Namba, T ., Kohsaka, S., Uchino, S. & Kida, S
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Journal Title
Hippocampus
Volume: (in press)
Issue: 7
Pages: 784-93
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine: implications for enhanced hippocampal adult neurogenesis.2014
Author(s)
Ishikawa, R., Kim, R., Namba, T., Kohsaka, S., Uchino, S. & Kida, S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Roles of CREB in the regulation of FMRP by group l metabotropic glutamate receptors in cingulate cortex.2012
Author(s)
Wang, H., Morishita, Y., Miura, D., Naranjo, J. R., Kida, S., Zhuo, M.
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Journal Title
Molecular Brain.
Volume: 5
Issue: 1
Pages: 27-27
DOI
Related Report
Peer Reviewed
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[Journal Article] Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity2012
Author(s)
Nomoto, M., Takeda, Y., Uchida, S., Mitsuda, K., Enomoto, H., Saito, K., Choi, T., Watabe, A.M., Kobayashi, S., Masushige, S., Manabe, T., Kida, S
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Journal Title
Mol Brain.
Volume: 5(On line)
Issue: 1
Pages: 8-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Enhancement of fear memory by retrieval through reconsolidation
Author(s)
Fukushima, H., Zhang, Y., Archbol, G., Ishikawa, R., Nader, K. Kida, S.
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Journal Title
Related Report
Peer Reviewed
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