Examination of angiogenic potential of brain-derived injury-induced neural stem cells
| Project/Area Number |
24650173
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529)
TAGUCHI Akihiko (財)先端医療振興財団, 研究部, 部長 (10359276)
SOMA Toshihiro 兵庫医科大学, 医学部, 准教授 (40273619)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 神経再生 / 血管新生 / 神経幹細胞 / 多能性幹細胞 / 脳梗塞 / 虚血 / ペリサイト / 神経分化 / 血管分化 |
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| Outline of Final Research Achievements |
In the present study, we investigated whether injury-induced neural stem/progenitor cells (iNSPCs) that are induced following ischemic stroke have the multipotency to differentiate into vascular cells as well as neural cells. We found that iNSPCs acquire multipotential stem cell activity following ischemic stroke and differentiate into both neural and vascular cells under certain conditions. These findings strongly suggest that neurogenesis and vasculogenesis can occur simultaneously. In addition, this indicates that iNSPCs play an important role in neurovasculogenesis under brain injuries, such as ischemic stroke.
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Report
(4 results)
Research Products
(4 results)
