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Examination of angiogenic potential of brain-derived injury-induced neural stem cells

Research Project

Project/Area Number 24650173
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Neuroscience in general
Research InstitutionHyogo Medical University

Principal Investigator

NAKAGOMI Takayuki  兵庫医科大学, 医学部, 准教授 (80434950)

Co-Investigator(Renkei-kenkyūsha) MATSUYAMA Tomohiro  兵庫医科大学, 医学部, 教授 (10219529)
TAGUCHI Akihiko  (財)先端医療振興財団, 研究部, 部長 (10359276)
SOMA Toshihiro  兵庫医科大学, 医学部, 准教授 (40273619)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords神経再生 / 血管新生 / 神経幹細胞 / 多能性幹細胞 / 脳梗塞 / 虚血 / ペリサイト / 神経分化 / 血管分化
Outline of Final Research Achievements

In the present study, we investigated whether injury-induced neural stem/progenitor cells (iNSPCs) that are induced following ischemic stroke have the multipotency to differentiate into vascular cells as well as neural cells. We found that iNSPCs acquire multipotential stem cell activity following ischemic stroke and differentiate into both neural and vascular cells under certain conditions. These findings strongly suggest that neurogenesis and vasculogenesis can occur simultaneously. In addition, this indicates that iNSPCs play an important role in neurovasculogenesis under brain injuries, such as ischemic stroke.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate into Neural and Vascular Lineage Cells.2015

    • Author(s)
      Nakagomi T, Kubo S, Nakano-Doi A, Sakuma R, Lu S, Narita A, Kawahara M, Taguchi A, Matsuyama T.
    • Journal Title

      Stem Cells.

      Volume: ー Issue: 6 Pages: 1962-1974

    • DOI

      10.1002/stem.1977

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Do Vascular Pericytes Contribute to Neurovasculogenesis in the CNS as Multipotent Vascular Stem Cells?2015

    • Author(s)
      Nakagomi T, Nakano-Doi A, Kawamura M, Matsuyama T.
    • Journal Title

      Stem Cells Dev.

      Volume: 未定 Issue: 15 Pages: 1730-1739

    • DOI

      10.1089/scd.2015.0039

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 脳梗塞後のBBB再構築能を持つ多能性幹細胞としてのペリサイト.2014

    • Author(s)
      中込 隆之、土居 亜紀子、佐久間 理香、河原 麻衣子、成田彩、田中康恵、柴田 啓貴、中田 雅代、川村美貴、松山 知弘.
    • Organizer
      第26回日本脳循環代謝学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳ペリサイトをめぐる脳保護と再生.2014

    • Author(s)
      松山知弘、中込隆之.
    • Organizer
      第26回日本脳循環代謝学会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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