A novel mechanism to transmit information of extracellular signals to the cytoskeleton
| Project/Area Number |
24650174
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Basic Biology |
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Principal Investigator |
SHINTANI Takafumi 基礎生物学研究所, 統合神経生物学研究部門, 准教授 (10312208)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 細胞骨格 / APC2 / 細胞移動 / 神経細胞 / 脳 / 神経回路 / 情報伝達 / 神経組織 / 神経回路形成 |
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| Outline of Final Research Achievements |
We analyzed Apc2-deficient mice, and found that a lack of Apc2 induces defective lamination in some brain regions, including the cerebral cortex, cerebellum, hippocampus, and olfactory bulb. APC2 is co-distributes with microtubules and actin fibers, and considered to be an essential mediator of the cytoskeletal regulation in response to extracellular signals. We further found that inhibition of APC2 functions on cytoskeleton by LRR is attenuated by a kinase inhibitor. We also generated LRR1- and LRR2-deficient mice.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Loss of Function Mutation in APC2 Causes Sotos Syndrome Features.2015
Author(s)
Almuriekhi, M., Shintani, T., Fahiminiya, S., Fujikawa, A., Kuboyama, K., Takeuchi, Y., Nawaz, Z., Nadaf, J., Kamel, H., Kitam, A.K., Samiha, Z., Mahmoud, L., Ben-Omran, T., Majewski, J. & Noda, M.
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Journal Title
Cell Reports
Volume: 10
Issue: 9
Pages: 1585-1598
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The R3 receptor-like protein-tyrosine phosphatase subfamily inhibits insulin signaling by dephosphorylating the insulin receptor at specific sites.2015
Author(s)
Shintani, T., Higashi, S., Takeuchi, Y., Gaudio, E., Trapasso, F., Fusco, A. & Noda, M.
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Journal Title
Journal of Biochemistry
Volume: -
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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