| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Our analyses revealed that, at the initial stages of striosome/matrix mosaic formation, striosome cells were mostly stationary whereas matrix cells were actively migrating in multi-directions. Despite their restricted migratory capability, striosome cells formed patchy clusters through their mutual homophilic interactions, mediated apparently by their intertwined extended processes. Actively migrating matrix cells, on the other hand, occupied the space in between striosome cells, suggesting that the way actively migrating matrix cells intermingle with mostly stationary striosome cells may determine the size, number and position of patchy clusters of striosome cells within the striatum. Our results also revealed that, at late-embryonic stages, actively migrating matrix cells exhibited repulsive migratory behaviors against patchy clusters of striosome cells, presumably contributing to the segregation and eventual formation of dichotomous homogeneous striosome/matrix compartments.
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