Striosome and matrix cell migration during mosaic formation in the developing striatum
| Project/Area Number |
24650176
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto University (2014)
Osaka University (2012-2013) |
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Principal Investigator |
TANABE Yasuto 京都大学, 医学(系)研究科, 研究員 (10311309)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 線条体 / モザイク構造 / 大脳基底核 / 細胞移動 |
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| Outline of Final Research Achievements |
Our analyses revealed that, at the initial stages of striosome/matrix mosaic formation, striosome cells were mostly stationary whereas matrix cells were actively migrating in multi-directions. Despite their restricted migratory capability, striosome cells formed patchy clusters through their mutual homophilic interactions, mediated apparently by their intertwined extended processes. Actively migrating matrix cells, on the other hand, occupied the space in between striosome cells, suggesting that the way actively migrating matrix cells intermingle with mostly stationary striosome cells may determine the size, number and position of patchy clusters of striosome cells within the striatum. Our results also revealed that, at late-embryonic stages, actively migrating matrix cells exhibited repulsive migratory behaviors against patchy clusters of striosome cells, presumably contributing to the segregation and eventual formation of dichotomous homogeneous striosome/matrix compartments.
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Report
(4 results)
Research Products
(1 results)
