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The barrier structure of glial limitans in the hippocampal fissureis is broken in the normal mouse, but maintained in the reeler.

Research Project

Project/Area Number 24650177
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Nerve anatomy/Neuropathology
Research InstitutionKobe University

Principal Investigator

TERASHIMA Toshio  神戸大学, 医学(系)研究科(研究院), 教授 (20101892)

Co-Investigator(Renkei-kenkyūsha) KIKKAWA Satoshi  神戸大学, 大学院医学研究科, 准教授 (90244681)
SETSU Tomiyoshi  神戸大学, 医学部, 技術専門員 (30403281)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords海馬裂 / リーラー / ヨタリ / リーリン / 貫通線維 / Dab1 / 海馬 / 海馬貫通線維 / Dab1
Outline of Final Research Achievements

In the present study, we injected BDA into the entorhinal cortex of the normal, reeler and yotari mice to examine the course of the entorhinohippocampal fibers, i.e., perforant pathway. BDA-labeled entorhinohippocampal fibers penetrated through the hippocampal fissure in the normal mouse, but they could not penetrate through the hippocampal fissure in the reeler and yotari mice. Next, we placed DiI crystals into the entorhinal cortex of the normal, reeler, and yotari mice during early postnatal weeks. DiI-labeled entorhinohippocampal fibers penetrated through the hippocampal fissure on P1 in the reeler and yotari mice, but no fibers which penetrated through the fissure were identified until P4, and all of DiI-labeled fibers ran in parallel to the fissure instead of perforating it. GFAP-immunopositive astroglia were accumulated along the hippocampal fissure both in the reeler and yotari mice, which may results in obstruction of elongation of entorhinohippocampal projection.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Promotion of Colorectal Cancer Invasion and Metastasis Through Activation of Notch-Dab1-Abl-RhoGEF Protein Trio.2015

    • Author(s)
      Sonoshita M, Itatani Y, Kakizaki F, Sakimura K, Terashima T, Katsuyama Y, Sakai Y, Taketo MM.
    • Journal Title

      Cancer Discov.

      Volume: 5 Issue: 2 Pages: 198-211

    • DOI

      10.1158/2159-8290.cd-14-0595

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoarchitecture of the olfactory bulb in the laggard mutant mouse.2014

    • Author(s)
      Yunus J, Setsu T, Kikkawa S, Sakisaka T, Terashima T.
    • Journal Title

      Neuroscience

      Volume: 275 Pages: 259-271

    • DOI

      10.1016/j.neuroscience.2014.06.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reelin受容体機能の多様性と脊椎動物脳の進化2013

    • Author(s)
      勝山裕、寺島俊雄
    • Journal Title

      生体の科学

      Volume: 64巻 Pages: 518-519

    • Related Report
      2013 Research-status Report
  • [Journal Article] Characterization of heterotopic cell clusters in the hippocampus of the rat after prenatal treatment of methylazoxymethanol acetate .2012

    • Author(s)
      Imai H, Setsu T, Terashima T, Sugioka K
    • Journal Title

      Congenit Anom

      Volume: 52 Issue: 2 Pages: 87-96

    • DOI

      10.1111/j.1741-4520.2012.00358.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subcortically and callosally projecting neurons are distinct neuronal pools in the motor cortex of the reeler mouse.2012

    • Author(s)
      Imai H, Yamamoto T, Katsuyama Y, Kikkawa S, Terashima T
    • Journal Title

      Kobe J Med Sci.

      Volume: 58

    • NAID

      110009592527

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes in the gene expression of zebrafish Reelin receptors during embryogenesis and hatching period2012

    • Author(s)
      Hideaki Imai, Yoshihito Oomiya, Satoshi Kikkawa, Wataru Shoji, Masahiko Hibi, Toshio Terashima, Yu Katsuyama
    • Journal Title

      Development, Growth & Differentiation

      Volume: Vol.54 Issue: 2 Pages: 253-263

    • DOI

      10.1111/j.1440-169x.2012.01327.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Sbno1は神経幹細胞の維持と分化に必須である2015

    • Author(s)
      勝山裕、中村龍司、杉山拓、大隅典子、阿部高明、相澤慎一、日比正彦、寺島俊雄.
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経奇形マウスラガードの小脳細胞構築2015

    • Author(s)
      ユヌス・ジュナエディ、 薛富義、吉川知志、匂坂敏朗、寺島俊雄.
    • Organizer
      第120回日本解剖学会総会・全国学術集会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Kif14 KOマウスとKif14Tgレスキューマウス脳の形態2014

    • Author(s)
      174.寺島俊雄, 薛富義, Junaedy Yunus, 匂坂敏朗. .  2014年11月29日(大阪).
    • Organizer
      第90回日本解剖学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-11-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発生期大脳皮質におけるDab1の分子内機能制御機構の解析2014

    • Author(s)
      173.並河知宏, 寺島俊雄, 吉川知志.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] リーリンシグナル伝達系の変異マウスreelerおよびyotariの顔面神経核と疑核の細胞構築異常2014

    • Author(s)
      薛富義、寺島俊雄
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      下野市(自治医科大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] ゼブラフィッシュdpf遺伝子の新規転写産物の解析2014

    • Author(s)
      鷲見拓哉、崎浜吉昭、寺島俊雄、吉川知志
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      下野市(自治医科大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] Cytoarchitecture of the olfactory bulb in the laggard mutant mouse2014

    • Author(s)
      Junaedy Yunus, Tomoyoshi Setsu, Toshiro Sakisaka,Toshio Terashima
    • Organizer
      第119回日本解剖学会総会
    • Place of Presentation
      下野市(自治医科大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] リーリンまたはDab1の欠損は小腸上皮細胞の分化に影響を与える2013

    • Author(s)
      山本達朗, 山本綾子, 永井 諒, 田邉弘基, 西村直道, 寺島俊雄.
    • Organizer
      第118回日本解剖学会総会全国学術集会
    • Place of Presentation
      高松
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュ小脳皮質発生におけるReelinシグナルの機能解析.2013

    • Author(s)
      吉川知志, 角本貴進, 崎浜吉昭, 、寺島俊雄
    • Organizer
      第118回日本解剖学会総会全国学術集会
    • Place of Presentation
      高松
    • Related Report
      2012 Research-status Report
  • [Presentation] 終脳特異的にDab1を欠損するマウス大脳の組織学的研究

    • Author(s)
      寺島俊雄、今井英明、 薛富義、勝山裕
    • Organizer
      第89回日本解剖学会近畿支部学術集会
    • Place of Presentation
      生駒市(奈良先端科学技術大学院大学)
    • Related Report
      2013 Research-status Report
  • [Presentation] Dab1N末端フラグメントの発現は発生期大脳皮質において異所的な細胞集積を誘導する

    • Author(s)
      並河知宏, 寺島俊雄, 吉川知志
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] ゼブラフィッシュ神経系の発生におけるReelin-Dab1シグナルの機能解析

    • Author(s)
      角本貴進, 寺島俊雄, 吉川知志
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Remarks] 神経発生学分野へようこそ 研究内容

    • URL

      http://www.med.kobe-u.ac.jp/anato1/study/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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