| Project/Area Number |
24650177
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kobe University |
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Principal Investigator |
TERASHIMA Toshio 神戸大学, 医学(系)研究科(研究院), 教授 (20101892)
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| Co-Investigator(Renkei-kenkyūsha) |
KIKKAWA Satoshi 神戸大学, 大学院医学研究科, 准教授 (90244681)
SETSU Tomiyoshi 神戸大学, 医学部, 技術専門員 (30403281)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 海馬裂 / リーラー / ヨタリ / リーリン / 貫通線維 / Ｄａｂ１ / 海馬 / 海馬貫通線維 / Dab1 |
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| Outline of Final Research Achievements |
In the present study, we injected BDA into the entorhinal cortex of the normal, reeler and yotari mice to examine the course of the entorhinohippocampal fibers, i.e., perforant pathway. BDA-labeled entorhinohippocampal fibers penetrated through the hippocampal fissure in the normal mouse, but they could not penetrate through the hippocampal fissure in the reeler and yotari mice. Next, we placed DiI crystals into the entorhinal cortex of the normal, reeler, and yotari mice during early postnatal weeks. DiI-labeled entorhinohippocampal fibers penetrated through the hippocampal fissure on P1 in the reeler and yotari mice, but no fibers which penetrated through the fissure were identified until P4, and all of DiI-labeled fibers ran in parallel to the fissure instead of perforating it. GFAP-immunopositive astroglia were accumulated along the hippocampal fissure both in the reeler and yotari mice, which may results in obstruction of elongation of entorhinohippocampal projection.
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