| Project/Area Number |
24650178
|
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Nerve anatomy/Neuropathology
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|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳・神経 / 発生 / 行動 / 進化 / 遺伝子 |
|---|
| Research Abstract |
Vertebrate brain has specific neuronal tracts called the early axonal scaffold, which appear during its early development. These tracts include the longitudinal and commissural axonal bundles such as posterior commissure (pc), which are highly conserved in gnathostomes. We investigated the brain development and gene expression of axon guidance molecules in vertebrates including lamprey, teleosts, amphibians and reptiles, and found that pc was conserved in vertebrates. We further demonstrated that inhibition of Slit2 and Robo2 in Xenopus larvae resulted in the abnormal pc morphology and uncoordinated swimming pattern. Thus, Slit-Robo interaction appears to be involved not only in the formation of pc but also in the establishment of functional brain elements that triggers a swimming behavior. In course of the evolution, Slit-Robo signaling will be contributed to the construction of pc which is a prerequisite for the subsequent development of complex neuronal circuits and functions.
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