| Project/Area Number |
24650206
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Hokkaido University |
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Principal Investigator |
TANAKA Masaki 北海道大学, 医学研究科, 教授 (90301887)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Masayori 北海道大学, 大学院医学研究科, 教授 (80314772)
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| Research Collaborator |
KUNIMATU Jun 北海道大学, 大学院医学研究科, 助教 (50632395)
MIYAMOTO Naoki 北海道大学, 大学院医学研究科, 助教 (00552879)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経科学 / 放射線治療装置 / 大脳皮質 / 霊長類 / 疾患モデル / 放射線定位照射 / 脳機能 / 神経心理 / 眼球運動 |
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| Research Abstract |
We developed a research technique to create animal model of brain lesions using the therapeutic linear accelerator. A total of four irradiations (130-150 Gy) were performed on the right frontal eye field of three Japanese monkeys. During a few weeks following irradiation, brain edema was evident in MRI and the performance of oculomotor tasks was declined; however, it recovered thereafter. For one monkey that was followed up about 8 months, the behavioral deficits reappeared in the 4th month and gradually progressed. Postmortem histological examination in two animals revealed large necrosis in the white matter and surrounding hemorrhage, but the cortical gray matter retained layers. This technique can be applied to deep brain structures in the future study. We now plan to use lower doses and will follow up longer interval.
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