Long-lasting synaptic plasticity subjected to the stochastic principle
Project/Area Number |
24650207
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Osaka University |
Principal Investigator |
OGURA Akihiko 大阪大学, 生命機能研究科, 教授 (30260631)
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Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Keiko (YOSHINO Keiko) 大阪大学, 大学院生命機能研究科, 准教授 (60256196)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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Keywords | シナプス可塑性 / シナプス新生 / シナプス廃止 / ゆらぎ / 脳切片培養 / 記憶固定 / 構造可塑性 |
Research Abstract |
We have proposed that 2 novel synaptic plasticity phenomena in the stable cultures of hippocampal slice should serve as suitable models for the analyses of cellular mechanisms underlying memory consolidation. Those are RISE (long-lasting synaptic enhancement after 3 repeated inductions of LTP supported by new synapse formation) and LOSS (long-lasting synaptic weakening after 3 repeated inductions of LTD supported by synapse elimination). In the present study we demonstrated that RISE develops through the following phases: a) the synapses are under constant generation and retraction; b) both the rates of generation and retraction increase transiently after a RISE-producing stimulus, c) the retraction rate returns to the basal level earlier than the generation rate, leading to a net increase in synapse density. However, LOSS develops without the phase of b. The 2 apparently symmetric phenomena are in fact asymmetric in the process of development.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells2012
Author(s)
Shimada, T.,Takai, Y., Shinohara, K., Yamasaki, A., Tominaga-Yoshino, K., Ogura, A., Toi, A., Asano, K., Shintani, N., Hayata-Takano, A., Baba, A. & Hashimoto, H.
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Journal Title
J. Neurochem
Volume: 122
Pages: 81-93
Related Report
Peer Reviewed
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[Journal Article] A simplified Method to Generate Serotonergic Neurons from mouse Embryonic Stem and Induced Pluripotent stem cells2012
Author(s)
Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H
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Journal Title
Journal of Neurochemistry
Volume: 122
Issue: 1
Pages: 81-93
DOI
Related Report
Peer Reviewed
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