Research Project
Grant-in-Aid for Challenging Exploratory Research
We have proposed that 2 novel synaptic plasticity phenomena in the stable cultures of hippocampal slice should serve as suitable models for the analyses of cellular mechanisms underlying memory consolidation. Those are RISE (long-lasting synaptic enhancement after 3 repeated inductions of LTP supported by new synapse formation) and LOSS (long-lasting synaptic weakening after 3 repeated inductions of LTD supported by synapse elimination). In the present study we demonstrated that RISE develops through the following phases: a) the synapses are under constant generation and retraction; b) both the rates of generation and retraction increase transiently after a RISE-producing stimulus, c) the retraction rate returns to the basal level earlier than the generation rate, leading to a net increase in synapse density. However, LOSS develops without the phase of b. The 2 apparently symmetric phenomena are in fact asymmetric in the process of development.
All 2014 2013 2012
All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (21 results) (of which Invited: 1 results) Book (3 results)
科学
Volume: 83 Pages: 256-262
Volume: 84 Pages: 256-262
Sci. Rep
Volume: 3 Issue: 1 Pages: 1957-1957
10.1038/srep01957
Volume: 3 Issue: 1 Pages: 3158-3158
10.1038/srep03158
日薬理誌
Volume: 142 Pages: 122-127
Scientific Reports
Volume: 3 Issue: 1
10.1038/srep03185
日本薬理学会雑誌
J. Neurochem
Volume: 122 Pages: 81-93
Journal of Neurochemistry
Volume: 122 Issue: 1 Pages: 81-93
10.1111/j.1471-4159.2012.07724.x
