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Development of a next-generation photo-stimulation device

Research Project

Project/Area Number 24650214
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Fusional basic brain science
Research InstitutionSaitama University

Principal Investigator

NAKAI Junichi  埼玉大学, 脳科学融合研究センター, 教授 (80237198)

Co-Investigator(Renkei-kenkyūsha) ANDO Keiko  埼玉大学, 脳科学融合研究センター, 特任 准教授 (40221741)
Research Collaborator OHKURA Masamichi  埼玉大学, 脳科学融合研究センター, 准教授 (70369172)
Project Period (FY) 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Keywords光遺伝学 / オプトジェネティクス / 第二高調波 / 極超短赤外線パルスレーザー / KTN 結晶 / 第二高調波発生 / 極長短赤外線パルスレーザー / KTN結晶
Research Abstract

In this study we developed a microscope equipment with which photosensitive molecules can be stimulated. In the equipment a pair of potassium tantalate niobate (KTN) crystals were used as a tunable lens, an electro-optic device that changes its refractive index by voltage. By changing the voltage which applied to the tunable KTN lens focus changed within ~23 microseconds. The speed of focus change was about 500~1000 times faster than that of the conventional piezo focuser. This technique can be applicable not only to scientific researches including neuroscience but also industrial field such as laser processing.

Report

(2 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )

Research Products

(29 results)

All 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (4 results) (of which Invited: 2 results) Remarks (19 results)

  • [Journal Article] Real-time visualization of neuronal activity during perception2013

    • Author(s)
      Muto A, Ohkura M, Abe G, Nakai J, Kawakami K
    • Journal Title

      Curr Biol.

      Volume: 23 Pages: 307-311

    • DOI

      10.1016/j.cub.2012.12.040

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses2013

    • Author(s)
      Tanaka M
    • Journal Title

      Mol Brain

      Volume: 6 Pages: 1-13

    • DOI

      10.1186/1756-6606-6-6

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd22012

    • Author(s)
      Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H
    • Journal Title

      Science

      Volume: 338(6104):226-3 Pages: 226-231

    • DOI

      10.1126/science.1222538

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012

    • Author(s)
      K. Tanaka, K. Matsui, T. Sasaki. H. Sano, S. Sugio, K. Fan, K. Ikenaka, R. Hen, J. Nakai, Y. Yanagawa, H. Hasuwa, K. Deisseroth, A. Yamanaka
    • Journal Title

      Cell Report

      Volume: 2 Pages: 397-406

    • DOI

      10.1016/j.celrep.2012.06.011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An improved genetically encoded red fluorescent Ca2+ indicator for detecting opticallyevoked action potentials2012

    • Author(s)
      M. Ohkura, T. Sasaki. C. Kobayashi, Y. Ikegaya, J. Nakai
    • Journal Title

      PLoS One

      Volume: 7 Pages: 1-7

    • DOI

      10.1371/journal.pone.0039933

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetically encoded green fluorescent Ca2+ indicators with improved detectability for neuronal Ca2+ signals2012

    • Author(s)
      M. Ohkura, T. Sasaki. J. Sadakari, K. Gengyo-Ando, Y. Kagawa-Nagamura, C. Kobayashi, Y. Ikegaya, J. Nakai
    • Journal Title

      PLoS One

      Volume: 7 Pages: 1-10

    • DOI

      10.1371/journal.pone.0051286

    • NAID

      120006386961

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Development and application of G-CaMP-type genetically encoded Ca2+ indicators2012

    • Author(s)
      Ohkura M, Nakai J
    • Organizer
      2012 Fall Janelia Conference "Fluorescent Proteins and Biological Sensors III
    • Place of Presentation
      Ashburn USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamic neuromuscular regulation in freely crawling C. elegans: multicellular Ca2+ imaging using GCaMPs2012

    • Author(s)
      Gengyo-Ando K, Usami A, Kagawa-Nagamura Y,Ohkura M, Ikegaya Y, Matsuki N, Nakai J
    • Organizer
      第35回神経科学学会年会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Final Research Report
  • [Presentation] Development and application of G-CaMP-type genetically encoded Ca2+ indicators.2012

    • Author(s)
      Ohkura M, Nakai J
    • Organizer
      2012 Fall Janelia Conference “Fluorescent Proteins and Biological Sensors III.”
    • Place of Presentation
      Ashburn USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dynamic neuromuscular regulation in freely crawling C. elegans: multicellular Ca2+ imaging using G-CaMPs.2012

    • Author(s)
      Gengyo-Ando K, Usami A, Kagawa-Nagamura Y, Ohkura M, Ikegaya Y, Matsuki N, Nakai J
    • Organizer
      第35回神経科学学会年会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 埼玉大学脳科学融合研究センター

    • URL

      http://subsi.saitama-u.ac.jp/

    • Related Report
      2012 Final Research Report
  • [Remarks] 報道関連情報(1)Kawabata I, Kashiwagi I, Obashi K, Ohkura M, Nakai J, Wynshaw-Boris A, Yanagawa Y and Okabe S:Moving synapses on developing neurons. Nature 姉妹誌注目のハイライト、2012 年3月7日.

    • Related Report
      2012 Final Research Report
  • [Remarks] (2)日経産業新聞: Muto A, Ohkura M et al, CurrentBiology 23, 1-5, 2013の論文に関 る記事が掲載された。内容:脳活動生きたまま観察.報道年月日:H25.2.13

    • Related Report
      2012 Final Research Report
  • [Remarks] Muto A, Ohkura M et al, Current Biology 23,1-5, 2013 の論文が国内外のインターネット サイト(以下)に大きく取り上げられた。

    • Related Report
      2012 Final Research Report
  • [Remarks] (1)ロイター

    • URL

      http://www.reuters.com/news/video-videoChannel=6

    • Related Report
      2012 Final Research Report
  • [Remarks] (2)サイエンスマガジン

    • URL

      http://news.sciencemag.org/sciencenow/2013/01/whats-your-fish-thinking.html

    • Related Report
      2012 Final Research Report
  • [Remarks] (3)サイエンティフィックアメリカン

    • URL

      https://www.scientificamerican.com/article.cfm?id=scientists-watch-a-fish-think

    • Related Report
      2012 Final Research Report
  • [Remarks] (4)ナショナルジオグラフィック

    • URL

      http://phenomena.nationalgeographic.com/2013/01/31/fish-watches-food-scientists-watch-fishs-thoughts/

    • Related Report
      2012 Final Research Report
  • [Remarks] (5)ワイアード

    • URL

      http://www.wired.com/wiredscience/2013/02/fish-neuron-video/

    • Related Report
      2012 Final Research Report
  • [Remarks] (6)ニューサイエンティスト

    • URL

      http://www.newscientist.com/article/dn23123-fluorescent-protein-lets-us-read-a-fishs-thoughts.html

    • Related Report
      2012 Final Research Report
  • [Remarks] (7)ネイキッドサイエンティスト

    • URL

      http://www.thenakedscientists.com/HTML/content/news-archive/news/1000067/

    • Related Report
      2012 Final Research Report
  • [Remarks] (8)ロサンゼルスタイムズ

    • URL

      http://www.latimes.com/news/science/sciencenow/la-sci-sn-fish-thought-brain-swim-zebrafish-20130131,0,5543599.story

    • Related Report
      2012 Final Research Report
  • [Remarks] (9)マイナビニュース

    • URL

      http://news.mynavi.jp/news/2013/02/01/182/

    • Related Report
      2012 Final Research Report
  • [Remarks] (10)カラパイア

    • URL

      http://karapaia.livedoor.biz/archives/52116852.html

    • Related Report
      2012 Final Research Report
  • [Remarks] (11)GIZMOND世界初!脳の電気的な動きをリアルタイムで可視化

    • URL

      http://www.gizmodo.jp/2013/02/post_11642.html

    • Related Report
      2012 Final Research Report
  • [Remarks] (12)コモンポスト

    • URL

      http://commonpost.info/?tag=%E3%82%BC%E3%83%96%E3%83%A9%E3%83%95%E3%82%A3%E3%83%83%E3%82%B7%E3%83%A5

    • Related Report
      2012 Final Research Report
  • [Remarks] (13)アメーバニュース

    • URL

      http://news.ameba.jp/20130214-547/

    • Related Report
      2012 Final Research Report
  • [Remarks] (3)大倉正道:蛍光分子センサーの開発と神経回路研究への応用.日本経団連埼玉埼経協ニュース371,18-18,(2012).

    • Related Report
      2012 Final Research Report
  • [Remarks] 埼玉大学脳科学融合研究センター

    • URL

      http://subsi.saitama-u.ac.jp/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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