| Project/Area Number |
24650232
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Nagoya University |
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Principal Investigator |
HONDO Eiichi 名古屋大学, 生命農学研究科, 教授 (30271745)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Noriyuki 物質・材料研究機構, 先端的共通技術部門, 主任研究員 (10302770)
OMATSU Tsutomu 東京農工大学, 農学部, 講師 (60455392)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 低重力 / マウス / エピジェネティクス / 次世代効果 / 次世代 |
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| Research Abstract |
This study aimed to clarify the effect of low-gravity on the vertebrates by mimicking its environment on the earth with realizing 0.58g. After the ICR mice were exposed to the low-gravity environment for 2 weeks, the weights of mice differed between the experimental group (low-gravity) and the control. They tended to decrease in the mice of the experimental group compared to the control. The methylation patterns of testicular genomic DNA in both groups were compared using chromatin immunoprecipitation method (ChIP), followed by the next generation sequencing. The contig-sequences by the sequencing corresponded to those inside or nearby 18 genes. Some of these genes are predicted Alzheimer related.
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