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Developmental transcriptome analysis of monkey brain for the establishment of human disease model

Research Project

Project/Area Number 24650234
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionCenter for Novel Science Initatives, National Institutes of Natural Sciences (2013)
Kyoto University (2012)

Principal Investigator

GO Yasuhiro  大学共同利用機関法人自然科学研究機構(新分野創成センター), 新分野創成センター, 特任准教授 (50377123)

Co-Investigator(Renkei-kenkyūsha) INOUE Kenichi  京都大学, 霊長類研究所, 助教 (90455395)
TOYODA Atsushi  国立遺伝学研究所, 特任准教授 (10267495)
WATAKABE Akiya  基礎生物学研究所, 准教授 (40290910)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsバイオリソース / モデル動物 / ゲノム / 霊長類 / 脳 / トランスクリプトーム / 疾患 / リサーチバイオリソース / エピジェネティクス
Research Abstract

For the establishment of primate model of human neuropsychiatric diseases and high-level cognitive functions, we performed spatio-temporal brain transcriptome analysis of macaques covering 12 brain regions and 7 developmental stages. High throughput transcriptome analysis by next generation sequencer reveals that profile of gene expression is more similar between brain regions within individuals than between individuals in the same brain regions.
We also aimed to elucidate the molecular basis of regional and circuit specificities at the single neuron level. To execute this, three different fluorescent retrograde tracers were injected into three distinct part of monkey brains (thalamus, striatum, pons), and three distinct signals on neurons were successfully confirmed in the prefrontal regions. At this moment, we are going to profile molecular signatures of regional and circuit specific neurons by collecting each neuron based on the fluorescent signal by laser capture microdissection.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (53 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (33 results) (of which Invited: 5 results) Book (8 results) Remarks (6 results)

  • [Journal Article] Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade2014

    • Author(s)
      Takashi Hayakawa, Nami Suzuki-Hashido, Atsushi Matsui, Yasuhiro Go
    • Journal Title

      Mol Biol Evol

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals.2014

    • Author(s)
      Uesaka M, Nishimura O, Go Y, Nakashima K, Agata K, Imamura T.
    • Journal Title

      BMC Genomics

      Volume: 15 Issue: 1 Pages: 35-35

    • DOI

      10.1186/1471-2164-15-35

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent expansions of the bitter taste receptor gene repertoire during evolution of mammals in the Euarchontoglires clade.2014

    • Author(s)
      Hayakawa T, Suzuki-Hashido N, Matsui A, Go Y.
    • Journal Title

      Molecular Biology and Evolution

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of taste signal transduction molecules in the caecum of common marmosets.2013

    • Author(s)
      Gonda S, Matsumura S, Saito S, Go Y, Imai H
    • Journal Title

      Biology Letters

      Volume: 9 Issue: 4 Pages: 20130409-20130409

    • DOI

      10.1098/rsbl.2013.0409

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regional DNA Methylation Differences between Humans and Chirnpanzees Are Associated with Genetic Changes, Transeriptional Divergence and Disease Genes2013

    • Author(s)
      福田 渓
    • Journal Title

      J. Hum, Genet

      Volume: 58 Issue: 7 Pages: 446-54

    • DOI

      10.1038/jhg.2013.55

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Eco-Geographical Diversification of Bitter Taste Receptor Genes ( TAS2Rs) among Subspecies of Chimpanzees ( Pan troglodytes).2012

    • Author(s)
      Takashi Hayakawa, Tohru Sugawara, Yasuhiro Go, Toshifumi Udono, Hirohisa Hirai, Hiroo Imai
    • Journal Title

      PLOS ONE

      Volume: 7 Issue: 8 Pages: 921-931

    • DOI

      10.1371/journal.pone.0043277

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 霊長類認知ゲノミクスと精神・神経疾患をターゲットとした霊長類モデル動物の探索2014

    • Author(s)
      郷康広
    • Organizer
      自然科学研究機構新分野創成センターシンポジウム 大規模脳神経回路機能マップのその先
    • Place of Presentation
      東京
    • Year and Date
      2014-01-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 霊長類認知ゲノミクスと精神・神経疾患をターゲットとした霊長類モデル動物の探索2014

    • Author(s)
      郷 康広
    • Organizer
      自然科学研究機構 新分野創成センターシンポジウム 「大規模脳神経回路機能マップのその先」
    • Place of Presentation
      星陵会館(東京都千代田区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ゲノムを通して我が身を知る?ヒトとサルの間にあるもの?2013

    • Author(s)
      郷康広
    • Organizer
      東北大・生体生命工学研究会
    • Place of Presentation
      仙台
    • Year and Date
      2013-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] マーモセット盲腸における味覚情報伝達分子群の発現解析2013

    • Author(s)
      権田彩、松村秀一、斉藤正一郎、郷康広、今井啓雄
    • Organizer
      第29回日本霊長類学会・日本哺乳類学会2013年度合同大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 情感はいかにゲノムによって左右され得るのか?2013

    • Author(s)
      郷康広
    • Organizer
      平成24年度京都大学霊長類研究所共同利用研究会「情感を育むゲノム・脳・社会環境」
    • Place of Presentation
      犬山
    • Year and Date
      2013-03-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2013

    • Author(s)
      郷康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」若手の会
    • Place of Presentation
      北海道支笏湖
    • Related Report
      2013 Final Research Report
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2013

    • Author(s)
      Yasuhiro Go
    • Organizer
      Cold Spring Harbor Meeting, Behavior & Neurogenetics of nonhuman primates
    • Place of Presentation
      Cold Spring Harbor, NY, US
    • Related Report
      2013 Final Research Report
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2013

    • Author(s)
      Yasuhiro Go, Takao Oishi, Shuji Shigenobu, Akiyoshi Kakita, Hiroyuki Nawa, Philipp Khaitovich
    • Organizer
      NGS現場の会第3回研究会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Deep Exome Sequencing in Macaque Monkeys for the Establishment of Primate Cognitive and Psychiatric Disease Model2013

    • Author(s)
      Yasuhiro Go, Atsushi Toyoda, Tomoyuki Aizu, Hiroo Imai, Hirohisa Hirai, Tetsuo Yamamori, Asao Fujiyama, Tadashi Isa
    • Organizer
      The 24th CDB meeting Genomics and Epigenomics with Deep Sequencing
    • Place of Presentation
      Kobe, JAPAN
    • Related Report
      2013 Final Research Report
  • [Presentation] オス・メス間ゲノムコンフリクティングとその生物学的意義の解明2013

    • Author(s)
      郷康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」班会議
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] オス・メス間ゲノムコンフリクティングとその生物学的意義の解明2013

    • Author(s)
      郷 康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」班会議
    • Place of Presentation
      ANAクラウンプラザホテル神戸(神戸市中央区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deep exome sequencing in macaque monkeys for the establishment of primate cognitive and psychiatric disease model.2013

    • Author(s)
      Yasuhiro Go, Atsushi Toyoda, Tomoyuki Aizu, Hiroo Imai, Hirohisa Hirai, Tetsuo Yamamori, Asao Fujiyama, Tadashi Isa
    • Organizer
      The 24th CDB meeting Genomics and Epigenomics with Deep Sequencing
    • Place of Presentation
      理化学研究所 発生・再生科学総合研究センター(神戸市中央区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2013

    • Author(s)
      郷 康広、大石高生、重信秀治、柿田明美、那波宏之、Philipp Khaitovich
    • Organizer
      第3回NGS現場の会研究会
    • Place of Presentation
      神戸国際会議場(神戸市中央区)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Spatiotemporal gene expression trajectory in the human and non-human ape brains2013

    • Author(s)
      Yasuhiro Go
    • Organizer
      Cold Spring Harbor Symposium ~Behavior & Neurogenetics of Nonhuman Primates~
    • Place of Presentation
      Cold Spring Harbor, New York, US
    • Related Report
      2013 Annual Research Report
  • [Presentation] Spatio-temporal gene expression trajectory2013

    • Author(s)
      郷 康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」若手の会
    • Place of Presentation
      支笏湖休暇村(千歳市支笏湖温泉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲノムを通して我が身を知る~ヒトとサルの間にあるもの~2013

    • Author(s)
      郷 康広
    • Organizer
      東北大・生体生命工学研究会
    • Place of Presentation
      東北大学(仙台市青葉区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Deep Exome Sequencing in Macaque Monkeys for the Establishment of Primate Cognitive and Psychiatric Disease Model2013

    • Author(s)
      Yasuhiro Go
    • Organizer
      The 24th CDB Meeting - Genomics and Epigenomics with Deep Sequencing
    • Place of Presentation
      Kobe
    • Related Report
      2012 Research-status Report
  • [Presentation] 新生遺伝子の転写調節機構の獲得と進化2012

    • Author(s)
      松村研哉、郷康広、大島一彦
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 真主齧類における苦味受容体の進化2012

    • Author(s)
      早川卓志、鈴木南美、松井淳、今井啓雄、平井啓久、郷康広
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Exomeデータを利用した霊長類の嗅覚受容体遺伝子の比較解析2012

    • Author(s)
      松井淳、郷康広、豊田敦、会津智幸、石崎比奈子、今井啓雄、藤山秋佐夫、平井啓久、新村芳人
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトとチンパンジーにおけるアリル特異的発現遺伝子の同定と遺伝子発現制御機構の進化2012

    • Author(s)
      郷康広
    • Organizer
      日本進化学会第14回大会、ワークショップ「遺伝子発現の相互作用と進化」
    • Place of Presentation
      東京
    • Year and Date
      2012-08-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 大型類人猿情報ネットワーク(GAIN)の10年の活動を振り返って2012

    • Author(s)
      落合知美、綿貫宏史朗、西村剛、郷康広、今井啓雄、伊谷原一、友永雅己、松沢哲郎
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] チンパンジーパーソナルゲノム研究2012

    • Author(s)
      郷康広、辰本将司、豊田敦、西村理、友永雅己、平井啓久、松沢哲郎、藤山秋佐夫、阿形清和
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-07
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 霊長類味覚受容体レパートリーの進化史2012

    • Author(s)
      早川卓志、鈴木南美、松井淳、今井啓雄、平井啓久、郷康広
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] ニホンザル味盲多型はどのようにして集団中に拡がったか2012

    • Author(s)
      鈴木南美、郷康広、松井淳、平井啓久、颯田葉子、今井啓雄
    • Organizer
      第28回日本霊長類学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-07-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of PTC"non-taster"Japanese macaques caused by TAS2R38 dysfunction2012

    • Author(s)
      Nami Suzuki, Atsushi Matsui, Yasuhiro Go, Yoshiro Ishimaru, Takumi Misaka, Keiko Abe, Hirohisa Hirai and Hiroo Imai
    • Organizer
      XVI International Symposium on Olfaction and Taste (ISOT XVI)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-06-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 霊長類ゲノム・トランスクリプトーム・メチローム研究2012

    • Author(s)
      郷康広
    • Organizer
      NGS現場の会第二回研究会
    • Place of Presentation
      大阪
    • Year and Date
      2012-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 霊長類ゲノム・トランスクリプトーム・メチローム研究2012

    • Author(s)
      郷 康広
    • Organizer
      第2回NGS現場の会研究会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Presentation] オス・メス間ゲノムコンフリクティングとその生物学的意義の解明2012

    • Author(s)
      郷 康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」班会議
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] オス・メス間ゲノムコンフリクティングとその生物学的意義の解明2012

    • Author(s)
      郷 康広
    • Organizer
      基礎生物学研究所所内セミナー
    • Place of Presentation
      岡崎
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ヒトとチンパンジーにおけるアリル特異的発現遺伝子の同定と遺伝子発現制御機構の進化2012

    • Author(s)
      郷 康広
    • Organizer
      第14回日本進化学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 霊長類エキソーム解析2012

    • Author(s)
      郷 康広
    • Organizer
      新学術領域研究「ゲノム・遺伝子相関」若手の会
    • Place of Presentation
      米原
    • Related Report
      2012 Research-status Report
  • [Presentation] ニホンザルエキソーム解析2012

    • Author(s)
      郷 康広
    • Organizer
      ナショナルバイオリソース(NBR)公開シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 日本心理学事典2013

    • Author(s)
      郷康広
    • Total Pages
      944
    • Publisher
      平凡社(分担執筆)
    • Related Report
      2013 Final Research Report
  • [Book] 最新 心理学事典2013

    • Author(s)
      藤永 保
    • Total Pages
      944
    • Publisher
      平凡社
    • Related Report
      2013 Annual Research Report
  • [Book] 日本のサル学のあした2012

    • Author(s)
      郷康広
    • Publisher
      京都通信社(分担執筆)
    • Related Report
      2013 Final Research Report
  • [Book] Monkeys, Apes, and Humans. -Primatology in Japan-2012

    • Author(s)
      Michael A. Huffman, Naofumi Nakagawa, Yasuhiro Go, Hiroo Imai, Masaki Tomonaga
    • Total Pages
      52
    • Publisher
      Springer-Verlag(分担執筆)
    • Related Report
      2013 Final Research Report
  • [Book] 受容体遺伝子の進化「化学受容の科学」2012

    • Author(s)
      郷康広
    • Publisher
      化学同人(分担執筆)
    • Related Report
      2013 Final Research Report
  • [Book] Post Genome Biology of Primates2012

    • Author(s)
      Hirohisa Hirai, Hiroo Imai, Yasuhiro Go
    • Publisher
      (Primatology Monographs)編集
    • Related Report
      2013 Final Research Report
  • [Book] Post-Genome Biology of Primates (Primatology Monographs)2012

    • Author(s)
      Hirohisa Hirai, Hiroo Imai, Yasuhiro Go
    • Total Pages
      297
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Book] Monkeys, Apes, and Humans: Primatology in Japan (SpringerBriefs in Biology)2012

    • Author(s)
      Michael A. Huffman, Naofumi Nakagawa, Yasuhiro Go, Hiroo Imai, Masaki Tomonaga
    • Total Pages
      62
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://cnsi.nins.jp/brain/

    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      https://sites.google.com/site/yasuhirogo/

    • Related Report
      2013 Final Research Report
  • [Remarks] 自然科学研究機構新分野創成センター活動報告書ダウンロードサイト

    • URL

      http://www.nins.jp/cnsi/download/index.php

    • Related Report
      2013 Annual Research Report
  • [Remarks] 郷康広個人のホームページ

    • URL

      https://sites.google.com/site/yasuhirogo/profile

    • Related Report
      2013 Annual Research Report
  • [Remarks] 京都大学霊長類研究所遺伝子情報分野

    • URL

      http://www.pri.kyoto-u.ac.jp/sections/molecular_biology/index.html

    • Related Report
      2012 Research-status Report
  • [Remarks] 郷康広個人のHP

    • URL

      https://sites.google.com/site/yasuhirogo/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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