New mouse model for an aural communication

• Project/Area Number: 24650235
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory animal science
• Research Institution: Osaka University
• Principal Investigator: UCHIMURA Arikuni 大阪大学, 生命機能研究科, 特任助教(常勤) (20513063)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: モデル動物 / 音声コミュニケーション

Outline of Final Research Achievements

To establish new mouse model for an aural communication, we studied our established mutant mouse, Sng mutant, which emits human audible range vocalization after sex maturation. Our study showed that Sng mutant would be a hopeful model to understand evolution of aural communication.

Research Products

• [Journal Article] Delineation of a frequency-organized region isolated from the mouse primary auditory cortex. (2015)
  • Author(s): Tsukano H, Horie M, Bo T, Uchimura A, Hishida R, Kudoh M, Takahashi K, Takebayashi H, Shibuki K
  • Journal Title: J Neurophysiol Volume: 印刷中 Issue: 7 Pages: 2900-2920
  • DOI: 10.1152/jn.00932.2014
  • Peer Reviewed / Open Access
• [Journal Article] International Symposium on “Germline Mutagenesis and Biodiversification” (2014)
  • Author(s): Arikuni Uchimura, Yuichiro Hara, Yoichi Gondo, Yusaku Nakabeppu
  • Journal Title: Genes & Genetic Systems Volume: 89 Issue: 2 Pages: 93-95
  • DOI: 10.1266/ggs.89.93
  • NAID: 130004687235
  • ISSN: 1341-7568, 1880-5779
  • Peer Reviewed / Open Access
• [Journal Article] Expansion of stochastic expression repertoire by tandem duplication in mouse Protocadherin-α cluster. (2014)
  • Author(s): Kaneko R, Abe M, Hirabayashi T, Uchimura A, Sakimura K, Yanagawa Y, Yagi T.
  • Journal Title: Sci Rep. Volume: 4 Issue: 1 Pages: 6263-6263
  • DOI: 10.1038/srep06263
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] マウス長期継代系統を用いた生殖系列突然変異率の閾値とその影響 (2014)
  • Author(s): 内村有邦、樋口真弓、水口洋平、西野穣、豊田敦、藤山秋佐夫、八木健
  • Organizer: 日本環境変異原学会 第43回大会
  • Place of Presentation: 一橋講堂 （東京都）
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] シンギングマウス(sng変異体)が示す新規ヒト可聴音域発声行動の解析 (2014)
  • Author(s): 有賀理瑛、井之上幸範、木津川尚史、内村有邦、八木健
  • Organizer: 第4回社会神経科学研究会「社会認知とコミュニケーション」
  • Place of Presentation: 生理学研究所 （愛知県）
  • Year and Date: 2014-10-30 – 2014-10-31
• [Presentation] 長期継代マウス系統を用いた突然変異率の推定と新しい遺伝学 (2014)
  • Author(s): 内村有邦、樋口真弓、水口洋平、西野穣、豊田敦、藤山秋佐夫、三浦郁生、若菜茂晴、八木健
  • Organizer: 日本遺伝学会第86回大会
  • Place of Presentation: 長浜バイオ大学 （滋賀県）
  • Year and Date: 2014-09-17 – 2014-09-19
  • Invited
• [Presentation] A singing strain in mutants from mutator mouse breeding (2014)
  • Author(s): 八木健、樋口真弓、水口洋平、豊田敦、藤山秋佐夫、三浦郁生、若菜茂晴、内村有邦
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Singing mice(sng mutant) exhibited a novel human-audible vocalization behavior (2014)
  • Author(s): 有賀理瑛、井之上幸範、木津川尚史、内村有邦、八木健
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] New genetics by using long-term breeding mutator mouse lines (2014)
  • Author(s): Arikuni Uchimura
  • Organizer: RIKEN GSC Tanabata Meeting
  • Place of Presentation: RIKEN Yokohama Campus
  • Year and Date: 2014-07-11
• [Presentation] DNA replication errors that fuel genetic and phenotypic diversities in mammals (2014)
  • Author(s): Arikuni Uchimura
  • Organizer: International Symposium on “Germline Mutagenesis and Biodiversification”
  • Place of Presentation: Kyushu University
  • Invited
• [Presentation] ヒト可聴音域で発声行動を示す新規変異マウスの解析 (2012)
  • Author(s): 八木健、内村有邦、井之上幸範、樋口真弓、日高裕子、涌井菜央、吉岡芳親、石川征司、楯谷一郎、仲川涼子、岡ノ谷一夫、三浦郁生、若菜茂晴
  • Organizer: 日本遺伝学会第８４回大会
  • Place of Presentation: 九州大学
  • Invited