| Project/Area Number |
24650242
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | National Institute of Genetics |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 代謝 / モデルマウス / 遺伝学 / ゲノム / 進化 / 変異誘発 |
|---|
| Research Abstract |
To understand the function of Hairless (Hr) in metabolism, we tried to develop a novel model mouse series in which Hr gene is conditionally targeted or over-expressed in a tissue-specific manner. Using Cre-loxP system, we developed conditional knockout mice of Hr gene, and CAG-loxP-CAT-pA-loxP-Hr transgenic mice that conditionally overexpress Hr gene. We also developed skeletal muscle specific Cre mice expressing Cre recombinase driven by Creatine kinase, muscle promoter. Using these genetically modified mice, we generated skeletal muscle specific Hr targeted
|
