| Project/Area Number |
24650244
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
TANOUE Akito 独立行政法人国立成育医療研究センター, 薬剤治療研究部, 部長 (60301800)
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| Research Collaborator |
NAKAMURA Kazuaki 独立行政法人国立成育医療研究センター, 研究所薬剤治療研究部・実験薬理研究室, 室長 (80392356)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 疾患モデル / ヒト肝型マウス / 胆道閉鎖症 / 免疫不全肝障害マウス / 疾患肝細胞移植マウス / 病態モデル |
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| Research Abstract |
In this study, we tried for development of humanized-liver mice in which the liver is reconstitute with human hepatocyte derived from some liver/biliary tract diseases. We demonstrated that we could produce some humanized-liver mice which have disease derived hepatocyte. Especially, we tried for producing humanized-liver using hepatocyte derived from biliary atresia. We showed that hepatocyte derived from biliary atresia produced human albumin and expressed drug metabolism enzymes in mouse liver. These results indicated that hepatocytes have normal hepatic functions even in biliary atresia. The results of this study indicated the possibility for development of humanized-disease liver mice and these mice may be useful for investigating pathological mechanism of liver/biliary tract diseases.
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