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Detectability of protein concentration changes in MRI

Research Project

Project/Area Number 24650246
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biological material science
Research InstitutionHokkaido University

Principal Investigator

YAMAMOTO Toru  北海道大学, 保健科学研究院, 教授 (80261361)

Co-Investigator(Kenkyū-buntansha) TSUTSUMI Kaori  北海道大学, 大学院保健科学研究院, 助教 (80344505)
THA Khin Khin  北海道大学, 大学院医学研究科, 特任講師 (20451445)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsMRI / タンパク / 誘電率 / 縦緩和 / 横緩和 / 高周波電気物性
Outline of Final Research Achievements

To investigate the possibility of noninvasive MR detection of pathologic changes in protein concentration, we measured the protein concentration dependency of permittivity, longitudinal and transverse relaxation rate. The transverse relaxation rate showed most accurate dependency. We also measured the transverse relaxation rate of cerebrospinal fluid in lateral ventricle and showed enough accuracy to detect pathologic―bacterial meningitis etc.―changes of protein concentration by developing a method to derive pixels that are free from cerebrospinal fluid flow.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results) (of which Invited: 2 results)

  • [Journal Article] Magnetic displacement force and torque on dental keepers in the static magnetic field of a magnetic resonance scanner2013

    • Author(s)
      Omatsu, M., Obata, T., Minowa, K., Yokosawa, K., Inagaki, E., Ishizaki, K., Shibayama, K., & Yamamoto, T.
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 1 Issue: 6 Pages: 1481-1486

    • DOI

      10.1002/jmri.24500

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy2012

    • Author(s)
      Khin Khin Tha
    • Journal Title

      BMC Neurology

      Volume: 12(39) Issue: 1

    • DOI

      10.1186/1471-2377-12-39

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] MR physics and physiology: what we see in proton signals from the human body2014

    • Author(s)
      Toru Yamamoto
    • Organizer
      14th Asia-Oceania Congress of Medical Physics & 12th South East Asia Congress of Medical Physics
    • Place of Presentation
      Ho Chi Minh City
    • Year and Date
      2014-10-23 – 2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 改良IR法解析法による高速高精度T1値測定の可能性2014

    • Author(s)
      高橋紗綾
    • Organizer
      第42回日本磁気共鳴医学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] グラジエントエコー法を用いた高速高精度T1値測定の可能性2014

    • Author(s)
      高橋紗綾
    • Organizer
      第107回日本医学物理学会学術大会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-04-10 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Feasibility study of fast and high-precision T1 measurements in MRI using gradient echo pulse sequence2014

    • Author(s)
      Saaya Takahashi
    • Organizer
      107th Scientific Meeting of Japan Society of Medical Physics
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Related Report
      2013 Research-status Report
  • [Presentation] Prediction of RF burning: mapping of high-SAR areas using a low-RF power scan2013

    • Author(s)
      Toru Yamamoto
    • Organizer
      International Society for Magnetic Resonance in Medicine 21th Annual Meeting and Exhibition
    • Place of Presentation
      Salt Lake City, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] MRIにおける金属材料の影響 -検査安全性およびアーチファクト-2013

    • Author(s)
      山本 徹
    • Organizer
      第23回日本磁気歯科学会学術大会
    • Place of Presentation
      登別市(第一瀧本館)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Prediction of RF Burning: Mapping of High-SAR Areas Using a Low-RF Power Scan2013

    • Author(s)
      Toru Yamamoto
    • Organizer
      ISMRM 21th Annual Meeting & Exhibition
    • Place of Presentation
      Salt Palace Convention Center(USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Prediction mapping of RF burning: demonstration by using a phantom with elaborate setup of an RF resonant loop2012

    • Author(s)
      Toru Yamamoto
    • Organizer
      ISMRM Scientific Workshop
    • Place of Presentation
      Lund University Hospital(Sweden)
    • Related Report
      2012 Research-status Report
  • [Presentation] MRIにおける人工熱傷の実現2012

    • Author(s)
      江刈内英輝
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 位相情報を利用した発熱部位予測マッピング2012

    • Author(s)
      高橋紗綾
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都国際会館(京都市)
    • Related Report
      2012 Research-status Report
  • [Presentation] MRIにおける熱傷の人工的再現とRF発熱予測マッピング2012

    • Author(s)
      唐 明輝
    • Organizer
      第 104 回日本医学物理学会学術大会
    • Place of Presentation
      つくば国際会議場(つくば市)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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