Detectability of protein concentration changes in MRI
| Project/Area Number |
24650246
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMAMOTO Toru 北海道大学, 保健科学研究院, 教授 (80261361)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Kaori 北海道大学, 大学院保健科学研究院, 助教 (80344505)
THA Khin Khin 北海道大学, 大学院医学研究科, 特任講師 (20451445)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | MRI / タンパク / 誘電率 / 縦緩和 / 横緩和 / 高周波電気物性 |
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| Outline of Final Research Achievements |
To investigate the possibility of noninvasive MR detection of pathologic changes in protein concentration, we measured the protein concentration dependency of permittivity, longitudinal and transverse relaxation rate. The transverse relaxation rate showed most accurate dependency. We also measured the transverse relaxation rate of cerebrospinal fluid in lateral ventricle and showed enough accuracy to detect pathologic―bacterial meningitis etc.―changes of protein concentration by developing a method to derive pixels that are free from cerebrospinal fluid flow.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Magnetic displacement force and torque on dental keepers in the static magnetic field of a magnetic resonance scanner2013
Author(s)
Omatsu, M., Obata, T., Minowa, K., Yokosawa, K., Inagaki, E., Ishizaki, K., Shibayama, K., & Yamamoto, T.
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Journal Title
Journal of Magnetic Resonance Imaging
Volume: 1
Issue: 6
Pages: 1481-1486
DOI
Related Report
Peer Reviewed
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