Manipulation of high-density lipoprotein structure and function for development of gene delivery carrier
Project/Area Number |
24650263
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Kyoto University |
Principal Investigator |
MURAKAMI Tatsuya 京都大学, 物質-細胞統合システム拠点, 准教授 (90410737)
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Project Period (FY) |
2012-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 遺伝子キャリア / ドラッグデリバリー / ナノバイオテクノロジー |
Research Abstract |
Our purpose in this study is to develop nanomaterials capable of delivering therapeutic gene to desired sites, such as cancer tissues, by utilizing natural nanomaterials in our body. High-density lipoprotein (HDL) is a natural nanomaterial that delivers lipids from peripheral tissues to the liver in our body. Due to its physiological functions, HDL have a propensity to accumulate in liver via HDL receptor recognition of apoA-I moiety in HDL. In order to weaken this recognition in the liver and then to redirect HDL to desired sites, we designed 9 apoA-I deletion mutants and succeeded in preparation of 8 HDL mutants. Among them, a few HDL mutants were found to show decreased affinity to the HDL receptor.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Helicity Selective Photoreaction of Single-walled Carbon Nanotubes with Organosulfur Compounds in the Presence of Oxygen2013
Author(s)
Maeda, Y.; Higo, J.; Amagai, Y.; Matsui, J.; Ohkubo, K.; Yoshigoe, Y.; Hashimoto, M.; Eguchi, K.; Yamada, M.; Hasegawa, T.; Sato, Y.; Zhou, J.; Lu, J.; Miyashita, T.; Fukuzumi, S.; Murakami, T.; Tohji, K.; Nagase, S; Akasaka, T.
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Journal Title
J. Am. Chem. Soc.
Volume: 135
Issue: 16
Pages: 6356-6362
DOI
Related Report
Peer Reviewed
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[Journal Article] Photodynamic and photothermal effecrts of semiconducting and metallic-enriched single-walled carbon nanotubes2012
Author(s)
Murakami, T., Nakatsuji, H., Inada, M., Matoba, Y., Umeyama, T., Tsujimoto, M. , Isoda, S., Hashida, M., Imahori, H.
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Journal Title
Journal of the American Chemical Society
Volume: 134
Issue: 43
Pages: 17862-17865
DOI
Related Report
Peer Reviewed
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[Journal Article] Creation of pure nanodrugs and their anticancer properties2012
Author(s)
H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
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Journal Title
Angew. Chem. Int. Ed
Volume: 51
Issue: 41
Pages: 10315-10318
DOI
Related Report
Peer Reviewed
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