| Project/Area Number |
24650265
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SERA Toshihiro 九州大学, 工学系研究員, 准教授 (40373526)
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| Co-Investigator(Renkei-kenkyūsha) |
UESUGI Kentaro 高輝度光科学研究センター, 研究員 (80344399)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 骨粗鬆症 / 全身性微振動刺激 / ランダム性 / 全身性微振動 / 不規則性 / アナボリック効果 / 骨微細構造 |
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| Outline of Final Research Achievements |
Whole body vibration (WBV) has the anabolic effects. In this study, we examined the effectiveness of noise-like vibration in preventing bone atrophy under disuse conditions and in promoting bone defect repair under estrogen-deficient conditions using mouse models. Noise-like WBV reduced the disuse-induced loss of cancellous bone compared with sine WBV and enlarged the medullary space without affecting cortical thickness. There was no effect of noise-like WBV on the amount of bone formation in defect repair; however, it increased the elastic modulus of regenerated bone. Furthermore, with concurrent use of parathyroid hormone, the new bone hardness became elevated. These results suggest the noise-like vibrational mode is favorable for enhancing the anabolic effect of WBV.
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