Destruction of the multidrug efflux transporter on the plasma membrane by photodynamic treatment
| Project/Area Number |
24650268
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
MIYAMOTO YUICHI 埼玉医科大学, 保健医療学部, 准教授 (00313718)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 生物・生体工学 / ナノバイオ / 細胞・組織 / 光線力学的治療 |
|---|
| Research Abstract |
Photodynamic therapy (PDT) established as a curative treatment for the cancer has acquired anticancer efficacy by producing reactive oxygen species on the plasma membrane or the cytoplasmic organelle. In this study, I employed PDT inducing no remarkable cell injury and investigate whether the PDT can reduce the degree of the resistance of cisplatin- or paclitaxel-resistant HeLa cells.
As the results, the cytotoxicity of paclitaxel for the paclitaxel-resistant HeLa cells was unchanged, whereas, the cytotoxicity of cisplatin for the cisplatin-resistant HeLa cells seems to increase. These findings suggest that the PDT is effective item for the reducing resistance of the anticancer drug- resistant cells possessing the cytoplasmic detoxification mechanism such as Glutathione(GSH) or metallothionein(MT) detoxification pathway.
|
Report
(3 results)
Research Products
(8 results)
