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Destruction of the multidrug efflux transporter on the plasma membrane by photodynamic treatment

Research Project

Project/Area Number 24650268
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionSaitama Medical University

Principal Investigator

MIYAMOTO YUICHI  埼玉医科大学, 保健医療学部, 准教授 (00313718)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生物・生体工学 / ナノバイオ / 細胞・組織 / 光線力学的治療
Research Abstract

Photodynamic therapy (PDT) established as a curative treatment for the cancer has acquired anticancer efficacy by producing reactive oxygen species on the plasma membrane or the cytoplasmic organelle. In this study, I employed PDT inducing no remarkable cell injury and investigate whether the PDT can reduce the degree of the resistance of cisplatin- or paclitaxel-resistant HeLa cells.
As the results, the cytotoxicity of paclitaxel for the paclitaxel-resistant HeLa cells was unchanged, whereas, the cytotoxicity of cisplatin for the cisplatin-resistant HeLa cells seems to increase. These findings suggest that the PDT is effective item for the reducing resistance of the anticancer drug- resistant cells possessing the cytoplasmic detoxification mechanism such as Glutathione(GSH) or metallothionein(MT) detoxification pathway.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Enhancement of the cytotoxic effects of bleomycin with permeabilization of the plasma membrane by Photo- frin-mediated photodynamic therapy in vitro2013

    • Author(s)
      Daisuke Nishikiori, Yuichi Miyamoto
    • Journal Title

      IFMBE Proceedings

      Volume: Vol. 43 Pages: 711-713

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of the cytotoxic effects of bleomycin with permeabilization of the plasma membrane by Photofrin-mediated photodynamic therapy in vitro2013

    • Author(s)
      Daisuke Nishikiori, Yuichi Miyamoto
    • Journal Title

      IFMBE Proceedings

      Volume: 43 Pages: 711-713

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enhancement of the cytotoxic effects of bleomycin with permeabilization of the plasma membrane by Photo- frin-mediated photodynamic therapy in vitro2013

    • Author(s)
      Daisuke Nishikiori, Yuichi Miyamoto
    • Organizer
      The 15^<th> International Conference on Biomedical Engineering
    • Place of Presentation
      シンガポール国立大学,シンガポール
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhancement of the cytotoxic effects of bleomycin with permeabilization of the plasma membrane by Photofrin-mediated photodynamic therapy in vitro2013

    • Author(s)
      Daisuke Nishikiori, Yuichi Miyamoto
    • Organizer
      ICBME 2013 The 15th International Conference on Biomedical Engineering
    • Place of Presentation
      National University of Singapore, Singapore
    • Related Report
      2013 Annual Research Report
  • [Presentation] Photodynamic therapyによる細胞内物質導入法の検討2012

    • Author(s)
      加藤隆太郎、宮本裕一
    • Organizer
      第5回智のシンポジウム‐文明・文化と科学技術‐
    • Place of Presentation
      東京大学
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Photodynamic treatmentによるBleomycinの細胞傷害効果の増強2012

    • Author(s)
      加藤麻衣子、宮本裕一
    • Organizer
      第5回智のシンポジウム‐文明・文化と科学技術‐
    • Place of Presentation
      東京大学
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Photodynamic treatment による細胞内物質導入法の検討2012

    • Author(s)
      加藤隆太郎、宮本裕一
    • Organizer
      第5回智のシンポジウム-文明・文化と科学技術-
    • Place of Presentation
      東京大学医学部教育研究棟(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] Photodynamic treatment によるBleomycinの細胞傷害効果の増強2012

    • Author(s)
      加藤麻衣子、宮本裕一
    • Organizer
      第5回智のシンポジウム-文明・文化と科学技術-
    • Place of Presentation
      東京大学医学部教育研究棟(東京都)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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