Development of a novel evaluation system for the barriers against drug delivery in stroma and mucus
| Project/Area Number |
24650282
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YASUNAGA Masahiro 国立がんセンター東病院, ユニット長 (80450576)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 蛍光相関分光 / 細胞外マトリックス / 間質バリヤ / ドラッグデリバリ / 粘液バリヤ / 抗がん剤 / 拡散係数 / ムチン / 粘膜バリヤ / 評価系 / ドラックデリバリ |
|---|
| Research Abstract |
A novel measurement system to evaluate the barriers agains drug delivery in extracellular spaces (stroma) and mucus was developed in this project. The standard matrices were the aqueous solutions of hyaluronan and jellyfish mucin (qniumucin) for stroma and mucus, respectively. Several molecules labeled with fluorescent dyes which simulate various drugs traveling through the extracellular spaces and mucus were also synthesized. A measurement instrument for fluoresecnce correlation spectroscopy (FCS) was optimized for the present evaluation.
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Report
(3 results)
Research Products
(61 results)
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[Journal Article] Discovery of an uncovered region in fibrin clots and its clinical significance.2013
Author(s)
Hisada Y, Yasunaga M, Hanaoka S, Saijou S, Sugino T, Tsuji A, Saga T, Tsumoto K, Manabe S, Kuroda J, Kuratsu J, Matsumura Y.
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Journal Title
Sci Rep.
Volume: 3
Issue: 1
Pages: 2604-2604
DOI
Related Report
Peer Reviewed
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[Journal Article] NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin2013
Author(s)
Takahashi A, Yamamoto Y, Yasunaga M, Koga Y, Kuroda J, Takigahira M, Harada M, Saito H, Hayashi T, Kato Y, Kinoshita T, Ohkohchi N, Hyodo I, Matsumura Y.
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Journal Title
Cancer Science
Volume: 104
Issue: 7
Pages: 920-925
DOI
Related Report
Peer Reviewed
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