| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
The lymphatic system plays a crucial role in tumor formation and metastasis progression. However, its function and structure have not been investigated fully. Here we show characteristics of lymphatic network between the subiliac lymph node (SiLN) and proper axillary lymph node (PALN), and of metastasis induction via lymphatic vessel. We used MXH10/Mo-lpr/lpr inbred mice that exhibit systemic lymphadenopathy. We found that bifurcation patterns for the lymphatic vessel that lies between the SiLN and the PALN. In most cases the lymphatic vessel had at least one bifurcation. Furthermore we found that metastasis was induced in the PALN by injection of tumor cells into the SiLN. The intranodal pressure increased in the SiLN and PALN during the course of LN metastasis. The findings provide new insights relevant to the investigation of the mechanisms of lymph node metastasis and and the development of treatment methods for lymph node metastasis, including drug delivery systems.
|
