Research Project
Grant-in-Aid for Challenging Exploratory Research
Therapeutic experiments were performed using a murine solid tumor to develop a novel combined-treatment between proton therapy and cisplatin. The results showed that the proton therapy combined with cisplatin inhibited tumor growth significantly in comparison to their monotherapies. Elemental analysis of the tumor treated with cisplatin-incorporated polymeric micelles (CDDP-micells) was performed to evaluate both concentration of the drug in the tumor tissue using the conventional PIXE analysis and its spatial distribution in the tumor using the submilli-PIXE analysis. The results showed higher drug concentration for the tumor treated with (CDDP-micells) compared to cisplatin whereas no significant difference in the concentration between CDDP-micells and cisplatin was observed for the normal tissue. This finding suggests that CDDP-micells not only provide superior therapeutic efficacy but also reduce side effects caused by conventional cisplatin when combined with proton therapy.
All 2013 2012
All Journal Article (9 results) (of which Peer Reviewed: 3 results) Presentation (8 results)
International Journal of PIXE
Volume: Vol. 23 Issue: 01n02 Pages: 69-75
10.1142/s0129083513400081
NMCC共同利用成果報告集
Volume: 19 Pages: 230-235
NMCC共同利用発表成果報文集
Volume: 22(1&2) Issue: 01n02 Pages: 37-43
10.1142/s0129083512400050
CYRIC Annual Report
Volume: 2010-2011 Pages: 46-48
Volume: 22 (Vol. 1 & 2) Pages: 37-43
Volume: 2010-2011 Pages: 49-51
NMCC 共同利用研究成果報文集
Volume: 18 Pages: 217-221
