| Project/Area Number |
24650292
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Nagaoka University of Technology |
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Principal Investigator |
WADAMORI Naoki 長岡技術科学大学, 工学(系)研究科(研究院), 助教 (60303179)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 光音響分光法 / 医用内視鏡 / 硬さ分析 / 深さ分析 / ニオイ分析 / 深部診断 / ニオイ診断 / 癌 / におい |
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| Outline of Final Research Achievements |
A miniaturized sensor was developed to determine the Young's modulus of tumors and diagnostic endoscopy of the existence of submucosal tumors, which based on photoacoustic (PA) spectroscopy. The sensor had a chamber height of 5.3mm and diameter of 5.8 mm; thus, this device is smaller than conventional endoscopes, the outer diameters of which are typically about 10 mm. A non-restrained methodology for determining the Young’s modulus of tumors was proposed based on the resonance frequency of the PA signal. The proposed approach was applied to silicone rubbers with six different Young’s moduli (30～574kPa) and showed good resolution (±2kPa) and high reproducibility. In experiments with a two-layer phantom, it was also confirmed that the measurable depth in PAS is sufficiently deep to reach the average gastric wall thickness of 5.0 mm, and the depth resolution in the range to the mucosal layer (which is less than 1 mm) of the gastric wall is ±0.25 mm.
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