Nonliner optical imaging for deep tissue using hollow fiber bundle
| Project/Area Number |
24650297
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Ehime University |
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Principal Investigator |
YUSUKE Oshima 愛媛大学, 医学部附属病院, 助教(病院教員) (10586639)
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| Co-Investigator(Kenkyū-buntansha) |
KATAGIRI Takashi 東北大学, 大学院工学研究科, 准教授 (90415125)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAMURA Takeshi 愛媛大学, 大学院医学系研究科, 教授 (70264421)
HIKITA Atsuhiko 愛媛大学, 大学院医学系研究科, 准教授 (60443397)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 深部イメージング / 非線形光学 / 中空ファイバ / 多光子励起蛍光 / 診断システム / イメージング / 内視鏡 / 第２高調波発生 / 非線形光学イメージング |
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| Research Abstract |
Optical imaging technique with a fluorescent label is a common tool to understand the mechanism of pathogenesis and the vital functions in cellular and molecular level. In this study, We developed a hollow fiber bundle as a basic technique for medical application of the optical imaging that combined deep tissue imaging with nonliner optics such as two-photon excited fluorescence and second harmonic generation (SHG) and endoscopic technique. In the result, the fiber coupling system was constructed and evaluated in biological samples. Two-photon fluorescence images and SHG images of the tissues in mice were successfully obtained using the hollow fiber bundle. These results suggest that the hollow fiber bundle technique is a promising as a practical tool for endoscopic application in the future.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] In vivo imaging of spinal cord in contusion injury model mice by multi-photon microscopy2014
Author(s)
Oshima Y, Horiuchi H, Ogata T, Hikita A, Miura H and Imamura T
Organizer
Photonics West 2014, Biomedical Optics (BIOS 2014), Imaging, Manipulation, and Analysis of Biomeleules, Cells, and Tissues XII 8947-7
Place of Presentation
San Francisco, California USA (口頭)
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