The development of the high precision navigation system of sentinel node in gastrointestinal cancer in an open MRI operating theater

• Project/Area Number: 24650298
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Kobe University
• Principal Investigator: KAKEJI Yoshihiro 神戸大学, 医学(系)研究科(研究院), 教授 (80284488)
• Co-Investigator(Kenkyū-buntansha): TOMIKAWA Morimasa 九州大学, 大学病院, 特任准教授 (60325454) ; IKEDA Tetsuo 九州大学, 大学病院, 准教授 (60585701) ; NAGAO Yoshihiro 九州大学, 大学病院, 医員 (70608968) ; MAEHARA Yoshihiko 九州大学, 大学院医学研究科, 教授 (80165662) ; HASHIZUME Makoto 九州大学, 大学院医学研究科, 教授 (90198664) ; KUMASHIRO Ryuichi 九州大学, 大学院医学研究科, 研究員 (10631591) ; OKI Eiji 九州大学, 大学院医学研究科, 准教授 (70380392)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: コンピュータ外科学 / ナビゲーション / センチネルリンパ節 / 胃癌 / Open MRI / コンピューター外科学

Outline of Final Research Achievements

This study aims to establish the navigation system of sentinel node in gastric cancer. In an open MRI operating theater, the laparoscopic monitor clearly showed the augmented reality models of the sentinel node which is enhanced by superparamagnetic iron oxide (SPIO) injected into the gastric mucosa endoscopically. After the appropriate condition setting, laparoscopic sentinel node dissection was technically able to be performed in this navigation system. Further clinical trials may elucidate the feasibility of this navigation system.

Research Products

• [Journal Article] Successful laparoscopic gastric resection and safe introduction of a single-incision technique for gastric submucosal tumors located near the esophagogastric junction. (2015)
  • Author(s): Kanaji S, Nakamura T, Yamamoto M, Imanishi T, Suzuki S, Tanaka K, Kuroda D, Kakeji Y
  • Journal Title: Surg Today Volume: 45 Issue: 2 Pages: 209-214
  • DOI: 10.1007/s00595-014-0940-2
  • Peer Reviewed / Open Access
• [Journal Article] Minimally invasive image analysis of biliary-pancreatic structure for preoperative simulation. (2014)
  • Author(s): Maeda T, Konishi K, Tanouez K, Taketomi A, Shirabe K, Maehara Y, Hashizume M.
  • Journal Title: Hepatogastroenterology Volume: 61 Pages: 1744-1747
  • Peer Reviewed / Open Access
• [Journal Article] omparison of open, laparoscopic, and hand-assisted laparoscopic devascularization of the upper stomach and splenectomy for treatment of esophageal and gastric varices: a single-center experience. (2014)
  • Author(s): Akahoshi T, Uehara H, Tomikawa M, Kawanaka H, Hashizume M, Maehara Y.
  • Journal Title: Asian J Endosc Surg. Volume: 7 Issue: 2 Pages: 138-144
  • DOI: 10.1111/ases.12096
  • Peer Reviewed / Open Access
• [Journal Article] Surgical outcomes in the newly introduced phase of intracorporeal anastomosis following laparoscopic distal gastrectomy is safe and feasible compared with established procedures of extracorporeal anastomosis (2014)
  • Author(s): Shingo Kanaji, Hitoshi Harada, Shunji Nakayama, Takashi Yasuda, Taro Oshikiri, Kentaro Kawasaki, Masashi Yamamoto, Tatsuya Imanishi, Tetsu Nakamura, Satoshi Suzuki, Kenichi Tanaka, Yasuhiro Fujino, Masahiro Tominaga, Yoshihiro Kakeji
  • Journal Title: Surg Endosc Volume: 28 Pages: 1250-1255
  • Peer Reviewed / Open Access
• [Journal Article] 本邦におけるロボット手術の導入と今後の展望 (2014)
  • Author(s): 家入里志, 橋爪 誠
  • Journal Title: Journal of Japan Society of Computer Aided Surgery Volume: 15 Issue: 4 Pages: 319-322
  • DOI: 10.5759/jscas.15.319
  • NAID: 130003398093
  • ISSN: 1344-9486, 1884-5770
  • Peer Reviewed / Open Access
• [Journal Article] 多元計算解剖学への新展開 (2014)
  • Author(s): 大内田研宙, 橋爪 誠
  • Journal Title: INNERVISION Volume: 29 Pages: 63-65
• [Journal Article] Extent of arterial tumor enhancement measured with preoperative MDCT gastrography is a prognostic factor in advanced gastric cancer after curative resection. (2013)
  • Author(s): Komori M, Asayama Y, Fujita N, Hiraka K, Tsurumaru D, Kakeji Y, Honda H.
  • Journal Title: AJR Am J Roentgenol. Volume: 201(2) Issue: 2 Pages: 253-261
  • DOI: 10.2214/ajr.12.9206
  • Peer Reviewed
• [Journal Article] Surgical outcomes in the newly introduced phase of intracorporeal anastomosis following laparoscopic distal gastrectomy is safe and feasible compared with established procedures of extracorporeal anastomosis. (2013)
  • Author(s): Kanaji S, Harada H, Nakayama S, Yasuda T, Oshikiri T, Kawasaki K, Yamamoto M, Imanishi T, Nakamura T, Suzuki S, Tanaka K, Fujino Y, Tominaga M, Kakeji Y.
  • Journal Title: Surg Endosc. Volume: -
  • Peer Reviewed
• [Journal Article] Progression from laparoscopic-assisted to totally laparoscopic distal gastrectomy: comparison of circular stapler (i-DST) and linear stapler (BBT) for intracorporeal anastomosis. (2013)
  • Author(s): Ikeda T., Kawano H., Hisamatsu Y., Ando K., Saeki H., Oki E., Ohga T., Kakeji Y., Tsujitani S., Kohnoe S., Maehara Y.
  • Journal Title: Surg Endosc Volume: 27(1) Issue: 1 Pages: 325-332
  • DOI: 10.1007/s00464-012-2433-y
  • Peer Reviewed
• [Journal Article] Total Laparoscopic Distal Gastrectomy for Elderly Patients with Gastric Cancer. (2013)
  • Author(s): Oki E., Sakaguchi Y., Ohgaki K., Saeki H., Ikegami T., Minami K., Yamashita Y., Toh Y., Soejima Y., Ando K., Mimori K., Watanabe M., Sugimachi K., Uchiyama H., Yoshizumi T., Kawanaka H., Morita M., Ikeda T., Maehara Y.
  • Journal Title: Fukuoka Acta Medica Volume: 104(9) Pages: 290-298
  • NAID: 120005372094
  • Peer Reviewed
• [Journal Article] Image-guided laparoscopic surgery in an open MRI operating theater. (2013)
  • Author(s): Tsutsumi N, Tomikawa M, Uemura M, Akahoshi T, Nagao Y, Konishi K, Ieiri S, Hong J, Maehara Y, Hashizume M.
  • Journal Title: Surg Endosc. Volume: 27(6) Issue: 6 Pages: 2178-84
  • DOI: 10.1007/s00464-012-2737-y
• [Journal Article] Robotic surgery for cancer. (2013)
  • Author(s): Ohuchida K, Hashizume M.
  • Journal Title: Cancer J. Volume: 19(2) Issue: 2 Pages: 130-2
  • DOI: 10.1097/ppo.0b013e31828da251
• [Journal Article] An augmented reality navigation system for pediatric oncologic surgery based on preoperative CT and MRI images. (2013)
  • Author(s): Souzaki R, Ieiri S, Uemura M, Ohuchida K, Tomikawa M, Kinoshita Y, Koga Y, Suminoe A, Kohashi K, Oda Y, Hara T, Hashizume M, Taguchi T.
  • Journal Title: J Pediatr Surg. Volume: 48 Issue: 12 Pages: 2479-83
  • DOI: 10.1016/j.jpedsurg.2013.08.025
  • Peer Reviewed
• [Journal Article] Formulation of wire control mechanism for surgical robot to create virtual reality environment aimed at conducting surgery inside the body. (2013)
  • Author(s): Suzuki N, Hattori A, Ieiri S, Tomikawa M, Kenmotsu H, Hashizume M.
  • Journal Title: Stud Health Technol Inform Volume: 184 Pages: 424-30
  • Peer Reviewed
• [Journal Article] Pure laparoscopic hepatectomy in semiprone position for right hepatic major resection. (2013)
  • Author(s): Ikeda T, Mano Y, Morita K, Hashimoto N, Kayashima H, Masuda A, Ikegami T, Yoshizumi T, Shirabe K, Maehara Y.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 20(2) Issue: 2 Pages: 145-50
  • DOI: 10.1007/s00534-012-0558-y
  • NAID: 10031168204
  • Peer Reviewed
• [Journal Article] Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection (2012)
  • Author(s): Kakeji Y, Yamamoto M, Ito S, Sugiyama M, Egashira A, Saeki H, Morita M, Sakaguchi Y, Toh Y, Maehara Y
  • Journal Title: Surg Today Volume: 42 Issue: 4 Pages: 351-358
  • DOI: 10.1007/s00595-011-0114-4
  • NAID: 10030546298
  • Peer Reviewed
• [Journal Article] Quality of life after laparoscopy-assisted pylorus-preserving gastrectomy: an evaluation using a questionnaire mailed to the patients. (2012)
  • Author(s): Tomikawa M, Korenaga D, Akahoshi T, Kohshi K, Sugimachi K, Nagao Y, Tsutsumi N, Takenaka K, Kakeji Y, Hashizume M, Maehara Y.
  • Journal Title: Surg Today Volume: 42(7): Issue: 7 Pages: 625-632
  • DOI: 10.1007/s00595-012-0182-0
  • NAID: 10030788161
  • Peer Reviewed
• [Journal Article] Esophageal replacement by colon interposition with microvascular surgery for the patients with thoracic esophageal cancer (2012)
  • Journal Title: The utility with super drainage. Dis Esophagus Volume: 26 Issue: 1 Pages: 50-56
  • DOI: 10.1111/j.1442-2050.2012.01327.x
  • Peer Reviewed
• [Journal Article] Patterns and time of recurrence after complete resection of esophageal cancer (2012)
  • Author(s): Sugiyama M, Morita M, Yoshida R, 他8名
  • Journal Title: Surg Today Volume: 42 Issue: 8 Pages: 752-758
  • DOI: 10.1007/s00595-012-0133-9
  • NAID: 10030949064
  • Peer Reviewed
• [Journal Article] Rigid and flexible endoscopic rendezvous in spatium peritonealis may be an effective tactic for laparoscopic megasplenectomy: significant implications for pure natural orifice translumenal endoscopic surgery. (2012)
  • Author(s): Tomikawa M, Akahoshi T, Kinjo N, Uehara H, Hashimoto N, Nagao Y, Kamori M, Kumashiro R, Maehara Y, Hashizume M.
  • Journal Title: Surgical Endoscopy Volume: 26(12) Issue: 12 Pages: 3573-9
  • DOI: 10.1007/s00464-012-2369-2
  • Peer Reviewed
• [Journal Article] [Robotic surgery for cancer treatment]. (2012)
  • Author(s): Oouchida K, Ieiri S, Kenmotsu H, Tomikawa M, Hashizume M.
  • Journal Title: Gan To Kagaku Ryoho Volume: 39(1) Pages: 1-7
  • Peer Reviewed
• [Journal Article] Augmented reality navigation system for laparoscopic splenectomy in children based on preoperative CT image using optical tracking device (2012)
  • Author(s): Ieiri S, Uemura M, Konishi K, Souzaki R, Nagao Y, Hashizume M, Taguchi T.
  • Journal Title: Pediatr Surg Int Volume: 28 Issue: 4 Pages: 341-346
  • DOI: 10.1007/s00383-011-3034-x
  • Peer Reviewed
• [Journal Article] Clinical Application of the Diagnostic and Therapeutic Model Assisted by the Computational Anatomy (2011)
  • Author(s): 橋爪 誠，富川盛雅
  • Journal Title: Medical Imaging Technology Volume: 29 Issue: 3 Pages: 143-148
  • DOI: 10.11409/mit.29.143
  • NAID: 130000886611
  • ISSN: 0288-450X, 2185-3193
  • Open Access
• [Journal Article] Laparoscopic resection for gastrointestinal stromal tumors in the stomach (2011)
  • Author(s): Kakeji Y., et al
  • Journal Title: Sugery Today online Volume: (Epub ahead of print) Issue: 6 Pages: 554-558
  • DOI: 10.1007/s00595-011-0072-x
  • NAID: 10030622072
  • Peer Reviewed
• [Journal Article] Totally laparoscopic colectomy with intracorporeal anastomosis achieved using a laparoscopic linear stapler : experience of a single institute (2011)
  • Author(s): Ikeda T., et al
  • Journal Title: Surgery Today Volume: 42 Issue: 1 Pages: 41-5
  • DOI: 10.1007/s00595-011-0003-x
  • Peer Reviewed
• [Presentation] 最新の3Dシステムと手術支援ロボットシステムの動向 ～内視鏡外科を事例として超精密加工技術に期待するもの～ (2014)
  • Author(s): 橋爪 誠
  • Organizer: 将来加工技術 第136委員会 創設50周年記念シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] インテリジェント手術支援ロボットシステムの開発 (2014)
  • Author(s): 橋爪 誠
  • Organizer: 第28回日本泌尿器内視鏡学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-26 – 2014-11-28
  • Invited
• [Presentation] 生体医工学・医用画像解析に基づいた、曲げて、捻って内部構造の変化がはっきり見え、電気メスで切れる、肝臓手術ナビゲーションシステムの検討 (2014)
  • Author(s): 池田哲夫、吉田佳弘、今井大祐、松本佳大、別城悠樹、赤星朋比古、木村光一、中川原英和、播本憲史、伊藤心二、山下洋市、池上徹、吉住朋晴、橋爪誠
  • Organizer: 第76回日本臨床外科学会
  • Place of Presentation: 福島
  • Year and Date: 2014-11-21
• [Presentation] 画像誘導装置の現状と今後の展望 (2014)
  • Author(s): 赤星 朋比古、富川 盛雅、池田 哲夫、橋爪 誠
  • Organizer: 第27回日本内視鏡外科学会総会
  • Place of Presentation: 岩手
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] 消化器・一般外科領域におけるナビゲーションサージェリーの現状と今後の展望 (2014)
  • Author(s): 富川 盛雅、植村 宗則、赤星 朋比古、内山 秀昭、遠藤 和也、是永 大輔、竹中 賢治、橋爪 誠
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 胃癌における機能温存手術 (2014)
  • Author(s): 鈴木 知志、金治 新悟、中村 哲、山本 将士、金光 聖哲、山下 公大、今西 達也、角 泰雄、田中 賢一、掛地 吉弘
  • Organizer: 第52回日本癌治療学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2014-08-28 – 2014-08-30
• [Presentation] 手術支援ナビゲーションシステムの開発と臨床応用における課題 (2014)
  • Author(s): 橋爪 誠
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] 胃がんに対する３D手術とロボット支援手術の経験 (2014)
  • Author(s): 大内田研宙，永井英司，仲田興平，山田大輔，中村勝也，清水周次，橋爪 誠，田中雅夫:
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 胃癌腹膜播腫に対する治療と展開 (2013)
  • Author(s): 掛地 吉弘
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] 外科療法 (2013)
  • Author(s): 掛地 吉弘
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 宮崎
• [Presentation] 腹腔鏡下前方切除術におけるリニアステープラーを用いた新しい吻合法の開発 (2013)
  • Author(s): 沖 英次、池田 哲夫、安藤 幸滋、井田 智、 木村 和恵、佐伯 浩司、森田 勝、楠本 哲也、 前原 喜彦
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] 胃・大腸癌組織におけるCXCL12/CXCR4発現による浸潤転移の分子機序とその制御 (2012)
  • Author(s): 掛地 吉弘、増田 隆伸、安藤 幸滋、佐伯 浩司、沖 英次、大賀 丈史、辻谷 俊一、鴻江 俊冶、米満 吉和、前原 喜彦
  • Organizer: 第67回日本消化器外科学会
  • Place of Presentation: 富山国際会議場
  • Invited
• [Presentation] コンピューター診断支援システムNewVESを応用した消化器外科領域の治療シミュレーション (2012)
  • Author(s): 富川 盛雅、小田 昌宏、神代 竜一、赤星 朋比古、橋本 直隆、長尾 吉泰、掛地 吉弘、森 健策、前原 喜彦、橋爪 誠
  • Organizer: 第67回日本消化器外科学会
  • Place of Presentation: 富山国際会議場
  • Invited
• [Presentation] 完全腹腔鏡下幽門側胃切除における三角吻合(Book Binding法)の工夫 (2012)
  • Author(s): 安藤 幸滋､佐伯 浩司､池田 哲夫､神代 竜一､沖 英次､大賀 丈史､掛地 吉弘､辻谷 俊一､鴻江 俊治､前川 喜彦
  • Organizer: 第67回日本消化器外科学会
  • Place of Presentation: 富山国際会議場
  • Invited
• [Presentation] OMRI装置を利用した広範囲レドックスイメージングを実現するESR局所コイルロボット.
  • Author(s): 豊田和孝, 村田正治, 橋爪 誠
  • Organizer: 第51回 日本生体医工学会大会
  • Place of Presentation: 福岡
• [Presentation] 手術支援ロボットの開発
  • Author(s): 橋爪 誠
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
• [Presentation] 九州大学病院におけるロボット手術の普及へ向けた取り組み-ロボット外科医の教育と新規国産手術支援ロボットの研究開発-.
  • Author(s): 家入里志, 宗崎良太, 長尾吉泰, 大内田研宙, 赤星朋比古, 大平 猛, 富川盛雅, 田口智章, 橋爪 誠
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 千葉
• [Presentation] 医科におけるロボット手術の最前線.
  • Author(s): 橋爪 誠
  • Organizer: 第22回日本顎変形症学会総会
  • Place of Presentation: 福岡
• [Presentation] Recent advances in robotic surgery.
  • Author(s): Hashizume M
  • Organizer: The Korean Journal of Endourology
  • Place of Presentation: Korea
• [Presentation] A newly-developed novel konjak Complex Marker (KCM) for MRI-guided intra-abdominal surgery.
  • Author(s): 徐 号, 橋爪 誠
  • Organizer: 第51回 日本生体医工学会大会
  • Place of Presentation: 福岡
• [Presentation] MRIガイド腹腔内臓器手術に対応する生体内用蒟蒻コンプレックスマーカーの開発
  • Author(s): 徐 号, 富川盛雅, 植村宗則, 家入里志, 橋爪 誠
  • Organizer: 第51回 日本生体医工学会大会
  • Place of Presentation: 福岡
• [Book] Patient Surveillance After Cancer Treatment, Current Clinical Oncology. (2013)
  • Author(s): Kakeji Y, Morita M, Maehara Y. Stomach Carcinoma Surveillance Counterpoint: Japan. Johnson FE, et al.
  • Total Pages: 538
  • Publisher: Springer Science + Business Media