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Identification of a genetic polymorphism that can predict the effects of resistance exercise training for the prevention of sarcopenia

Research Project

Project/Area Number 24650331
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Rehabilitation science/Welfare engineering
Research InstitutionJuntendo University (2013)
Tokai University (2012)

Principal Investigator

MACHIDA Shuichi  順天堂大学, スポーツ健康科学研究科, 准教授 (40421226)

Co-Investigator(Kenkyū-buntansha) FUKU Noriyuki  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40392526)
田中 雅嗣  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)
Co-Investigator(Renkei-kenkyūsha) TANAKA Masashi  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60155166)
Project Period (FY) 2012-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsサルコペニア / 遺伝子多型 / 筋力トレーニング / 骨格筋量
Research Abstract

Sarcopenia is characterized by a progressive decrease of skeletal muscle mass and function (strength or performance) with aging. Sarcopenia has become a highly significant public health problem, physical disability, metabolic syndrome and cardiovascular diseases. Resistance exercise training is well established as the most effective non-pharmacological intervention to restrict or prevent sarcopenia. However, previous studies observed enormous inter-individual variability in muscle mass and strength. Inter-individual variations for muscle mass and strength may be due to environmental factors, genetic factors and/or gene-environment interactions. Here we tried to identify genetic polymorphisms associated with trainability of skeletal muscle mass after resistance exercise training in elderly Japanese people with low relative skeletal muscle mass.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report

Research Products

(26 results)

All 2014 2013 2012 Other

All Journal Article Presentation Book Remarks

  • [Journal Article] The Q223R polymorphism in the leptin receptor associates with objectively measured light physical activity in free-living Japanese2014

    • Author(s)
      Murakami H, Iemitsu M, Fuku N, Sanada K, Gando Y, Kawakami R, Miyachi M
    • Journal Title

      Physiol Behav

      Volume: 129 Pages: 199-204

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts2014

    • Author(s)
      Pinós T, Fuku N, Cámara Y, Arai Y, Abe Y, Rodríguez-Romo G, Garatachea N, Santos-Lozano A, Miro-Casas E, Ruiz-Meana M, Otaegui I, Murakami H, Miyachi M, Garcia-Dorado D, Hinohara K, Andreu AL, Kimura A, Hirose N, Lucia A.
    • Journal Title

      Age

      Volume: 36 Pages: 933-43

    • DOI

      10.1007/s11357-013-9593-0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Genomics of elite sporting performance: what little we know and necessary advances2014

    • Author(s)
      Garatachea N, Emanuele E, Calero M, Fuku N, Arai Y, Abe Y, et al.
    • Journal Title

      Adv Genet

      Volume: 53C Pages: 123-149

    • DOI

      10.1016/j.exger.2014.02.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting2013

    • Author(s)
      Kurosaka M, Machida S
    • Journal Title

      Cell proliferation.

      Volume: 46 Pages: 365-373

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exome sequencing of senescence-accelerated mice (sam) reveals deleterious mutations in degenerative disease-causing genes2013

    • Author(s)
      Tanisawa K., Mikami E., Fuku N., Honda Y., Honda S., Ohsawa I., Ito M., Endo S., Ihara K., Ohno K., Kishimoto Y., Ishigami A., Maruyama N., Sawabe M., Iseki H., Okazaki Y., Hasegawa-Ishii S., Takei S., Shimada A., Hosokawa M., Mori M., Higuchi K., Takeda T., Higuchi M., Tanaka M.
    • Journal Title

      Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes

      Volume: 14(1): Pages: 1-15

    • DOI

      10.1186/1471-2164-14-248

    • NAID

      120006651025

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases.2013

    • Author(s)
      Zhou H, Mori S, Kou I, Fuku N, Naka Mieno M, Honma N, Arai T, Sawabe M, Tanaka M, Ikegawa S, Ito H
    • Journal Title

      Journal of Human Genetics

      Volume: 58 Pages: 109-112

    • DOI

      10.1038/jhg.2012.145

    • NAID

      10031156433

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Interleukin-6-induced satellite cell proliferation is regulated by induction of the JAK2/STAT3 signalling pathway through cyclin D1 targeting. Cell proliferation2013

    • Author(s)
      Kurosaka M, Machida S.
    • Journal Title

      Cell proliferation

      Volume: 46 Pages: 365-373

    • DOI

      10.1111/cpr.12045

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-6-induced satellite cell proliferation is regulated through induction of signal downstream target Cyclin D1 of JAK2/STAT3 signaling pathway2013

    • Author(s)
      Kurosaka M, Machida S
    • Journal Title

      Cell Proliferation

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of 29C>T polymorphism in the transforming growth factor-beta1 gene with lean body mass in community-dwelling Japanese population2012

    • Author(s)
      Fuku N, Mori S, Murakami H, Gando Y, Zhou H, Ito H, Tanaka M, Miyachi M
    • Journal Title

      Geriatr Gerontol Int

      Volume: 12 Pages: 292-297

    • DOI

      10.1111/j.1447-0594.2011.00768.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial macrohaplogroup associated with muscle power in healthy adults2012

    • Author(s)
      Fuku N, Murakami H, Iemitsu M, Sanada K, Tanaka M, Miyachi M
    • Journal Title

      Int J Sports Med

      Volume: 33 Pages: 292-297

    • DOI

      10.1055/s-0031-1301317

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 柔道選手におけるACE遺伝子多型と全身持久力の関連性について2013

    • Author(s)
      廣川彰信,位高駿夫,上水研一朗,有賀誠司,宮崎誠司,町田修一
    • Organizer
      第24回日本臨床スポーツ医学会学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 介護・寝たきりにならない身体づくりを創造する-高齢者をサポートする運動と栄養の効果的な組み合わせを探る-2013

    • Author(s)
      町田修一
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京(ランチョンセミナー)
    • Related Report
      2013 Final Research Report
  • [Presentation] 柔道選手におけるACTN3遺伝子多型についての研究-T大学柔道部を対象として-2013

    • Author(s)
      上水研一朗,位高駿夫,廣川彰信,有賀誠司,町田修一
    • Organizer
      日本武道学会第46回大会
    • Place of Presentation
      茨城
    • Related Report
      2013 Final Research Report
  • [Presentation] 柔道の競技レベルを規定するアスリート遺伝子の探索-ACEとACTN3を組み合わせた検討-2013

    • Author(s)
      位高駿夫,廣川彰信,上水研一朗,有賀誠司,町田修一
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of the ACTN3 and ACE Polymorphism in Japanese judo athletes2013

    • Author(s)
      Agemizu K, Hirokawa S, Itaka T, Aruga S, Machida S
    • Organizer
      The VIII International Judo Research Symposium
    • Place of Presentation
      Brazil
    • Related Report
      2013 Final Research Report
  • [Presentation] Polymorphism of the IGF-2 gene specifies competitive capacity of Japanese judo players2013

    • Author(s)
      Itaka T, Hirokawa S, Agemizu K, Aruga S, Machida S
    • Organizer
      18th annual Congress of the European College of Sports Science
    • Place of Presentation
      Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Polymorphism of the IGF-2 gene specifies competitive capacity of Japanese judo players2013

    • Author(s)
      Itaka T, Hirokawa S, Agemizu K, Aruga S, Machida S.
    • Organizer
      18th annual Congress of the European College of Sports Science
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] Polymorphism of the IGF-2 gene specifies competitive capacity of Japanese judo players2013

    • Author(s)
      Itaka T, Hirokawa S, Agemizu K, Aruga S, Machida S
    • Organizer
      2013 ECSS (European College of Sport Science) Congress
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2012 Research-status Report
  • [Presentation] サルコペニアの予防・改善を目的とした介入プログラムの開発2012

    • Author(s)
      町田修一
    • Organizer
      第67回日本体力医学会大会シンポジウム
    • Place of Presentation
      岐阜
    • Related Report
      2013 Final Research Report
  • [Presentation] Association of the ACTN3 and ACE Polymorphism in Japanese judo athletes

    • Author(s)
      Agemizu K, Hirokawa S, Itaka T, Aruga S, Machida S.
    • Organizer
      The VIII International Judo Research Symposium
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Related Report
      2013 Annual Research Report
  • [Presentation] 介護・寝たきりにならない身体づくりを創造する -高齢者をサポートする運動と栄養の効果的な組み合わせを探る-

    • Author(s)
      町田修一
    • Organizer
      第68回日本体力医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] サルコペニアの予防・改善を目的とした介入プログラムの開発

    • Author(s)
      町田修一
    • Organizer
      第67回日本体力医学会大会
    • Place of Presentation
      長良川国際会議場・岐阜都ホテル
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 運動,老化の生物学2014

    • Author(s)
      町田修一(分担執筆)(石井直明編集)
    • Publisher
      (株)化学同人(2014年7月刊行予定)
    • Related Report
      2013 Final Research Report
  • [Book] 老化の生物学(石井直明編集)2014

    • Author(s)
      町田修一(分担執筆)
    • Total Pages
      250
    • Publisher
      (株)化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] 老化の生物学2013

    • Author(s)
      町田修一(分担執筆)
    • Total Pages
      293
    • Publisher
      化学同人
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      https://www.juntendo.ac.jp/graduate/kenkyudb/search/researcher.php?MID=5037

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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