| Project/Area Number |
24650332
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
Hara Takatoshi 東京慈恵会医科大学, 医学部, 助教 (40619889)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Syu 東京慈恵会医科大学, リハビリテーション医学講座, 教授 (30256466)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 脳卒中 / 経頭蓋的磁気刺激療法 / 失語症 / エイリアンハンド症候群 / 注意障害 / Alien hand syndrome / fNIRS / リハビリテーション / 高次脳機能障害 / 経頭蓋磁気刺激 / Alien hand syndrom / 脳血流 |
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| Outline of Final Research Achievements |
the effects of repetitive transcranial magnetic stimulation in the higher brain dysfunction and Imaging study have not been examined fully. We investigated the change of image in chronic post-stroke patients, pre- and post-intervention, consisting of rTMS and intensive rehabilitation. In Alien hand syndrome, We have the first case of improving AHS and upper limb functions by low-frequency repetitive transcranial magnetic stimulation(rTMS) to the contralesional cerebral hemisphere and intensive occupational therapy. And this technique had the effects reduced inter hemispheric inhibition by fNIRS. In the chronic post-stroke aphasic patients, fMRI-guided LF-rTMS combined with intensive ST affect CBF and contribute to the improvement of language function of post-stroke aphasic patients.
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