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Analysis and modeling of brain's dynamics of sleep stage transitions

Research Project

Project/Area Number 24650366
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Physical education
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMOTO Yoshiharu  東京大学, 教育学研究科(研究院), 教授 (60251427)

Co-Investigator(Kenkyū-buntansha) TOGO Fumiharu  東京大学, 教育学研究科(研究院), 准教授 (90455486)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords睡眠段階遷移 / 睡眠圧 / 睡眠脳波 / 睡眠段階 / 遷移現象 / 睡眠の質
Research Abstract

We investigated the effects of an increase sleep pressure after exercise on dynamic aspects of sleep and electroencephalogram during Stage2 in healthy subjects to reveal the characteristics of switches which regulate sleep stage transitions. All the subjects were negative for sleep disorders. After exercise, the subjects showed a significantly (p < 0.05) greater probability of transition from Stage1 to Stage2 and a significantly (p < 0.05) lower rate of transition from Stage1 to wake than baseline. For electroencephalogram during Stage2 just before transitions to other sleep stages, the number of sleep spindles and K-complexes significantly (p < 0.05) increased before transitions to slow wave sleep (SWS) and wake or Stage1 compared to transitions to other sleep stages, respectively. These results suggest that dynamic sleep morphology might be simulated using mathematical models of a Stage2-wake/Stage1 switch, a Stage2-REM switch, and a Stage2-SWS switch.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2013

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome.2013

    • Author(s)
      Kishi, A., F. Togo, D.B. Cook, M. Klapholz, Y. Yamamoto, D.M. Rapoport, and B.H. Natelson.
    • Journal Title

      Physiological Reports

      Volume: 1 Issue: 6 Pages: e00152-e00152

    • DOI

      10.1002/phy2.152

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Effects of exercise on sleep morphology in healthy controls and patients with chronic fatigue syndrome2013

    • Author(s)
      Kishi, A., F. Togo, D.M. Rapoport, and B.H. Natelson
    • Organizer
      American Psychosomatic Society 71st Annual Meeting
    • Place of Presentation
      InterContinental Miami, Miami, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of exercise on sleep stage dynamics in healthy controls and patients with chronic fatigue syndrome2013

    • Author(s)
      Kishi, A., F. Togo, D.M. Rapoport, and B.H. Natelson
    • Organizer
      SLEEP 2013, the 27th Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of exercise on sleep stage dynamics in healthy controls and patients with chronic fatigue syndrome.2013

    • Author(s)
      Kishi, A., F. Togo, D.M. Rapoport, and B.H. Natelson.
    • Organizer
      SLEEP 2013, the 27th Annual Meeting of the Associated Professional Sleep Societies
    • Place of Presentation
      Baltimore, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of Exercise on Sleep Morphology in Healthy Controls and Patients with Chronic Fatigue Syndrome.2013

    • Author(s)
      Kishi, A., F. Togo, D.M. Rapoport, and B.H. Natelson.
    • Organizer
      American Psychosomatic Society 71st Annual Meeting
    • Place of Presentation
      Miami, USA
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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