| Project/Area Number |
24650412
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | ナットウキナーゼ / 血液凝固系因子 / 血液線溶系因子 / 血栓 / 血栓溶解作用 / 線溶系 / 凝固系 / 納豆菌培養エキス / D-dimer / フィブリン／フィブリノーゲン分解産物 / アンチトロンビン / フィブリノーゲン / 血栓予防 |
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| Outline of Final Research Achievements |
Our aim was to determine the quantitative effects of a single-dose of Nattokinase (NK) administration on coagulation/fibrinolysis parameters comprehensively in healthy male subjects. A double-blind, placebo-controlled cross-over NK intervention study was carried out in 15 healthy young males. Following the baseline blood draw, each subject was randomized to receive either a single-dose of 2,000 FU NK or placebo with subsequent cross-over of the groups. Subjects donated blood samples at 2, 4, 6 and 8 hours following administration. As a result, D-dimer concentrations and blood fibrin/fibrinogen degradation products after NK administration elevated significantly. Factor VIII activity declined, blood antithrombin concentration was higher, and the activated partial thromboplastin time prolonged significantly following NK administration. In conclusion, thus, a single-dose of NK administration appears enhancing fibrinolysis and anti-coagulation via several different pathways simultaneously.
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