| Project/Area Number |
24650438
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | Tsukuba University of Technology |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 心不全 / 糖尿病 / 自律神経 / 副交感神経 / 鍼 / 心拍変動 / 高周波数電位 / ラット / 鍼治療 / 心臓自律神経 / 交感神経 / 高血圧 / 心臓リモデリング / 高周波数成分（HF） / 心拍変動（HRV） / 鍼刺激 |
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| Outline of Final Research Achievements |
The pathophysiology of heart failure is characterized by hemodynamic abnormalities that result in neurohormonal activation and autonomic imbalance with increase in sympathetic activity and withdrawal of vagal activity. To improve this autonomic nervous imbalance in heart failure, electrical intervention that stimulates vagus nerve directly by implantable stimulator. However, this method is expensive and invasive for the patients. Acupuncture for “Zusanli” is known to have an effect as sympathetic nerve suppression in patients with hypertension. In this study, electrical stimulation by acupuncture (EA) on “Zusanli” was employed for several rat heart failure models. As a result, improvement of parasympathetic nerve activity was suspected by EA on “Zusanli” even in severe condition of rat heart failure model.
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