| Project/Area Number |
24650444
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Kyoto University |
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Principal Investigator |
YAMADA Minoru 京都大学, 医学(系)研究科(研究院), 助教 (30525572)
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| Co-Investigator(Kenkyū-buntansha) |
AOYAMA Tomoki 京都大学, 大学院医学研究科, 准教授 (90378886)
荒井 秀典 京都大学, 医学(系)研究科(研究院), 教授 (60232021)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Hidenori 京都大学, 大学院医学研究科, 教授 (60232021)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サルコペニア / 高齢者 / バイオマーカー / 介入 / テーラーメード介入 |
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| Research Abstract |
Sarcopenia, the age-related loss of skeletal muscle mass, is highly prevalent in older adults. The first aim of this study was to evaluate the biomarker of sarcopenia in community-dwelling Japanese older adults (Study 1). The second aim was to investigate the effects of the combination of resistance training with a multinutrient supplementation on muscle mass and physical performance in frail older adults with low muscle mass (Study 2).
Healthy older adults (321) participated in the study 1. In the study 2, a total of 77 participants were divided into the exercise group with supplementation (S/Ex: n = 38) and exercise group (Ex: n = 39), and followed for 3 months.
The study 1 was suggested that the serum IGF-1 and grip strength are the biomarker for the sarcopenia. The study 2 suggest that the combination of resistance training and multinutritional supplementation may be more effective at improving sarcopenia than an intervention only based on resistance training.
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