Development of practical biomarkers for metabolic disease risks
| Project/Area Number |
24650448
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
GODA Toshinao 静岡県立大学, 食品栄養科学部, 教授 (70195923)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Kazuki 山梨大学, 大学院総合研究部, 准教授 (80423838)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | バイオマーカー / 健康診査 / サイトカイン / 食習慣 / 慢性炎症 |
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| Outline of Final Research Achievements |
We have explored practical biomarkers for overall evaluation of metabolic disease risks, focusing on the inflammation-related biomarkers that have been suggested to be involved in the onset and development of metabolic diseases. The principal component 1 score from metabolic syndrome diagnostic parameters was strongly associated with not only plasma IL-1β and IL-6 levels, but also with plasma γ-GTP and ALT levels. Follow-up of the health checkup participants for 5 years revealed that the changes in blood HbA1c levels were positively associated with the initial plasma levels of γ-GTP and ALT. The results of this study suggest that plasma γ-GTP and ALT levels in combination, are the valid and practical biomarkers for prediction of metabolic disease risks.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Plasma TNF-a is associated with inflammation and nutritional status in community-dwelling Japanese elderly.2015
Author(s)
Oe, Y., Mochizuki, K., Miyauchi, R., Misaki, Y., Kasezawa, N., Tohyama, K., Goda, T.
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Journal Title
J. Nutr. Sci. Vitaminol.
Volume: 未定
Related Report
Peer Reviewed
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[Journal Article] Serum fatty acid binding protein 4 concentrations are positively and independently associated with blood pressure and abdominal fat among parameters health check-ups in middle-aged general Japanese males.2015
Author(s)
Yamada M., Mochizuki, K., Honma, K., Miyauchi, R., Kasezawa, N., Tohyama, K., Goda, T.
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Journal Title
J. Nutr. Sci. Vitaminol.
Volume: 未定
Related Report
Peer Reviewed
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