| Project/Area Number |
24650450
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUZUI Masatoshi 明治大学, 経営学部, 教授 (10187693)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | スポーツ免疫学 / 循環調節 / 自律神経調節 / ＮＫ細胞 / 末梢反射 / NK細胞 |
|---|
| Research Abstract |
In this study, we found that when the muscle metaboreflex activation by forearm muscle ischemia after the handgrip exercise caused increase in sympathetic nerve activity and secretion of catecholamine without large rise in circulatory blood flow, the circulating count of NK cells as well as NK cell cytotoxicity increased. In addition, when passive bicycle exercise induced increase in circulatory blood flow and the fall of catecholamine concentration, we found that the circulating count of helper T cells, killer T cells and B cells increased. These findings advance elucidation of regulatory mechanisms of immune-cells dynamic state in circulatory blood during exercise, and will be a significant academic base in considering the efficacy of the exercise training in promotion of health.
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