Exploration of key factors for recovering the gastrointestinal tract by the approach of comparative biology and the application to the enteral feeding
| Project/Area Number |
24650458
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General human life sciences
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Akinori 静岡大学, 理学部, 講師 (70432193)
HAYASHI Hisayoshi 静岡県立大学, 食品栄養学部, 准教授 (40238118)
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| Co-Investigator(Renkei-kenkyūsha) |
GODA Toshinao 静岡県立大学, 食品栄養学部, 教授 (70195923)
YAMAUCHI Kiyoshi 静岡大学, 理学部, 教授 (50201827)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 絶食 / 消化管機能低下 / アフリカツメガエル / ラット / 消化吸収関連遺伝子 / ヒストンアセチル化修飾 / 低栄養 / 小腸 / マウス / ヒト培養細胞 / 絶食-再摂食 / 栄養素消化吸収関連遺伝子 / ヒストン修飾 / Pre-mRNA / クロマチン / mRNA分解 / 無尾両生類 / 経腸栄養 |
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| Outline of Final Research Achievements |
In this study, we found that expressions of genes related to nutrient digestion and absorption, and their transcriptional factors in the small intestine were reduced by the fasting in rats and african clawed frogs. There expressions were rapidly recovered in the african clawed frogs, but less in rats, by the re-feeding. Histone modifications such as acetylations in these genes were enhanced in african clawed frogs, but not in rats, by the re-feeding. Food factors inducing the histone acetylation such as short-chain fatty acids and medium-chain fatty acids has the potency of enhancing genes related to nutrient digestion and absorption in human intestine-like culture cells.
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Report
(4 results)
Research Products
(7 results)
