Investigation of soy protein isolate in whole body glucose metabolism

• Project/Area Number: 24650487
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kanazawa University
• Principal Investigator: INOUE Hiroshi 金沢大学, 脳・肝インターフェースメディシン研究センター, 教授 (50397832)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 栄養学 / 糖尿病 / 肝糖代謝 / タンパク質

Research Abstract

Soy protein isolate (SPI) is known to improve insulin resistance. Therefore, we measured parameters of whole body glucose metabolism in mice fed with high fat (HF) diet containing casein or SPI as main protein source for 4 weeks. Between mice fed with casein-HF diet and with SPI-HF diet, there is no difference in body weight, blood glucose levels, and plasma insulin levels. At 4 weeks after the initiation of HF feeding, we performed glucose tolerance test to evaluate whole body glucose tolerance between these two group and found no difference of glucose tolerance in these two groups. These findings suggested thatSPI has little effect to improve insulin resistance under the condition of 4 week HF feeding.

Research Products

• [Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action (2013)
  • Author(s): Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H
  • Journal Title: Diabetes Volume: 62(7) Pages: 2266-77
  • Peer Reviewed
• [Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43 (2013)
  • Author(s): Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
  • Journal Title: Nat Commun Volume: 4 Pages: 1829-1829
  • NAID: 120005244704
  • Peer Reviewed
• [Journal Article] Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice (2013)
  • Author(s): Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H, Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T
  • Journal Title: Diabetologia Volume: 56(6) Pages: 1383-93
  • Peer Reviewed
• [Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin (2013)
  • Author(s): Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
  • Journal Title: Diabetologia Volume: 56(5) Pages: 1088-97
  • Peer Reviewed
• [Journal Article] Histidine augments the suppression of hepatic glucose production by central insulin action. (2013)
  • Author(s): Kimura K, Nakamura Y, Inaba Y, Matsumoto M, Kido Y, Asahara S, Matsuda T, Watanabe H, Maeda A, Inagaki F, Mukai C, Takeda K, Akira S, Ota T, Nakabayashi H, Kaneko S, Kasuga M, Inoue H.
  • Journal Title: Diabetes Volume: 62 Issue: 7 Pages: 2266-77
  • DOI: 10.2337/db12-1701
  • Peer Reviewed
• [Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. (2013)
  • Author(s): Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G.
  • Journal Title: Nat Commun. Volume: 4 Issue: 1 Pages: 1829-1829
  • DOI: 10.1038/ncomms2852
  • NAID: 120005244704
  • Peer Reviewed
• [Journal Article] Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice. (2013)
  • Author(s): Lee YS, Sasaki T, Kobayashi M, Kikuchi O, Kim HJ, Yokota-Hashimoto H, Shimpuku M, Susanti VY, Ido-Kitamura Y, Kimura K, Inoue H, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ohya S, Tanaka Y, Kitajima S, Kitamura T.
  • Journal Title: Diabetologia Volume: 56(6) Issue: 6 Pages: 1383-1393
  • DOI: 10.1007/s00125-013-2879-z
  • Peer Reviewed
• [Journal Article] Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin (2013)
  • Author(s): Asahara S
  • Journal Title: Diabetologia Volume: なし Issue: 5 Pages: 1088-1097
  • DOI: 10.1007/s00125-013-2849-5
  • Peer Reviewed
• [Presentation] 第4回「食」による生活習慣病予防医学の展開シンポジウム「食と肝糖産生の制御」 (2013)
  • Author(s): 井上啓
  • Organizer: 金沢大学次世代重点研究プログラム
  • Place of Presentation: 金沢
  • Year and Date: 2013-11-21
• [Presentation] ヒスチジンは、中枢神経を介してインスリン作用による肝糖産生抑制を増強する (2013)
  • Author(s): 木村久美、松本道宏、春日雅人、井上啓
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-11
• [Presentation] ヒスチジンは、中枢神経を介してインスリン作用による肝糖産生抑制を増強する (2013)
  • Author(s): 木村久美、井上啓
  • Organizer: 第67回日本栄養・食糧学会
  • Place of Presentation: 名古屋
  • Year and Date: 2013-05-25
• [Presentation] ヒスチジンは、中枢神経を介してインスリン作用による肝糖産生抑制を増強する (2013)
  • Author(s): 木村久美、井上啓
  • Organizer: 第67回 日本栄養・食糧学会
  • Place of Presentation: 名古屋
• [Presentation] (2012)
  • Author(s): 井上啓
  • Organizer: 第3回「食」による生活習慣病予防医学の展開シンポジウム「ヒスチジンによる肝糖代謝調節」
  • Place of Presentation: 金沢
  • Year and Date: 2012-12-06
• [Presentation] 食と肝糖産生の制御
  • Author(s): 井上啓
  • Organizer: 第４回「食」による生活習慣病予防医学の展開シンポジウム
  • Place of Presentation: 金沢
• [Presentation] ヒスチジンは、中枢神経を介してインスリン作用による肝糖産生抑制を増強する
  • Author(s): 井上 啓
  • Organizer: 第３回「食」による生活習慣病予防医学の展開シンポジウム
  • Place of Presentation: KKRホテル金沢（石川県）
  • Invited
• [Remarks]
  • URL: http://inoue.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学脳・肝インターフェースメディシン研究センター生体統御学部門代謝生理学
  • URL: http://inoue.w3.kanazawa-u.ac.jp/index.html
• [Remarks] 金沢大学脳・肝インターフェースメディシン研究センター井上研究室業績一覧
  • URL: http://inoue.w3.kanazawa-u.ac.jp/achievement.html
• [Patent(Industrial Property Rights)] 肝糖産生モニターマウス (2012)
  • Inventor(s): 井上啓
  • Industrial Property Rights Holder: 井上啓
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-095075
  • Filing Date: 2012-04-18