| Project/Area Number |
24650490
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyushu University |
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Principal Investigator |
FURUSE Mitsuhiro 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
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| Co-Investigator(Kenkyū-buntansha) |
YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生活リズム / 概日時計 / アミノ酸 / 栄養 / 時計遺伝子 |
|---|
| Research Abstract |
Disruption of the circadian clock by irregular illumination in the modern world causes many diseases, including sleep disorders, obesity, diabetes, hypertension, and cancer. It is important to identify the nutritional factors that can modulate the properties of the circadian clock. This study identified the functional amino acids that can modulate the activity rhythm or expression of clock genes in the brain and peripheral organs. This study further confirmed the utility of these amino acids for clock-related diseases using animal models. These data highlight the importance of amino acid nutrition for the regulation of the circadian disruption.
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