| Project/Area Number |
24650503
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Jissen Women's University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | apolipoprotein B48 / intestine / cell culture / transcription / APOBEC1 / curcumin / genistein / resveratrol / chylomicron / apolipoproteinB48 / hyperlipidemia / Caco-2 / culture / 動脈硬化 / mRNA編集 / リポタンパク / アポリポタンパクB48 / 転写制御 / クルクミン / レスベラトロール / ゲニステイン / アポタンパクB48 / カイロミクロン / トリグリセライド / 食後高脂血症 |
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| Outline of Final Research Achievements |
In order to elucidate the effects of food ingredients on chylomicron metabolism, which leads to postprandial hyperlipidemia a potent risk factor of cardiovascular diseases, we ivetigated the secretion of chylomicron triglyceride and apoB48, for which we have developed monoclonal ELISA, from human intestinal cell Caco-2.
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