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Objective evaluation of the effects of food fragrance on the stress response in the brain

Research Project

Project/Area Number 24650506
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Eating habits, studies on eating habits
Research InstitutionToho University

Principal Investigator

MASUO Yoshinori  東邦大学, 理学部, 教授 (60301553)

Co-Investigator(Renkei-kenkyūsha) HIRUTA Nobuyuki  東邦大学, 医学部, 准教授 (50201736)
Research Collaborator SATO Tadaaki  東邦大学, 薬学部, 講師 (80287549)
KUROKI Nobuo  東邦大学, 医学部, 教授 (80138990)
RAKWAL Randeep  筑波大学, 大学院生命環境科学研究科, 教授 (70590850)
SALZET Michel  リール第1大学, Laboratoire de Spectrométrie de Masse Biologique Fondamentale & Appliquée, 教授
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsストレス / 海馬 / 前頭葉皮質 / 炎症 / 神経細胞死 / 脳 / 中脳 / MKP-1 / NGFR / Arc / アロマ / MAPK / BDNF / TrkB
Outline of Final Research Achievements

We performed behavioral, anatomical and molecular biological analyses in animals exposed to stress. The results suggest that a coffee aroma may inhibit an inflammation in the hippocampus and frontal cortex caused by stress. The expression of inflammation-related genes showed a tendency of increment in the human leukocyte, which tended to be decreased by coffee aroma. Additionally we observed the effects of several kinds of aroma on behavior and gene expression in the brain, and the results suggested that the fragrance might contribute to prevention of brain dysfunction by stress.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (8 results)

  • [Journal Article] Expression of BDNF and TH mRNA in the brain following inhaled administration of α-pinene2015

    • Author(s)
      Kasuya H, Okada N, Kubohara M, Satou T, Masuo Y, Koike K
    • Journal Title

      Phytother Res

      Volume: 29 Issue: 1 Pages: 43-47

    • DOI

      10.1002/ptr.5224

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal effects of bisphenol A on dopaminergic neurons: an experiment on adult rats2014

    • Author(s)
      Ishido M, Masuo Y
    • Journal Title

      Open Environmental Sciences

      Volume: 8 Pages: 9-17

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] コーヒーの香りがもたらす抗不安様作用についての研究2015

    • Author(s)
      阿久津伸, 西井淳雄, 佐藤忠章, 増尾好則, 小池一男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(兵庫県神戸市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒノキ精油の主要な揮発性成分α-ピネンが情動行動と脳内遺伝子発現量に及ぼす影響2015

    • Author(s)
      粕谷ひかる, 岡田成美, 久保原美佳, 佐藤忠章, 増尾好則, 小池一男
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(兵庫県神戸市)
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effects of coffee aroma on the stress: analysis of behavior and gene expression in the mice2015

    • Author(s)
      Nishii A, Akutsu S, Mabuchi A, Kasuya H, Satou T, Masuo Y
    • Organizer
      第92回日本生理学会大会・第120回日本解剖学会総会・全国学術集会 合同大会
    • Place of Presentation
      神戸国際会議場・展示場(神戸ポートアイランド(兵庫県神戸市))
    • Year and Date
      2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] コーヒーの香りによるストレス抑制効果の検討2014

    • Author(s)
      西井淳雄, 阿久津伸, 馬渕亮史, 粕谷ひかる, 佐藤忠章, 増尾好則
    • Organizer
      第18回日本統合医療学会・第17回日本アロマセラピー学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-12-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stress-responsive biomarker candidates in human blood2014

    • Author(s)
      Tsuneishi W, Mabuchi A, Suzuki K, Sato T, Hiruta N, Kuroki N, Masuo Y
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会 合同年会
    • Place of Presentation
      奈良県文化会館(奈良県奈良市)
    • Year and Date
      2014-10-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血液解析によるストレス度調査について2014

    • Author(s)
      佐藤俊哉, 常石和瑚, 馬渕亮史, 増尾好則, 藤井悠, 黒木宣夫, 蛭田啓之, 武城英明
    • Organizer
      第7回佐倉病院学術集会
    • Place of Presentation
      東邦大学医療センター佐倉病院(千葉県佐倉市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] From stress to depression2013

    • Author(s)
      Suzuki K, Rakwal R, Shibato J, Masuo Y
    • Organizer
      11th World Congress of Biological Psychiatry (WFSBP Congress 2013)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Studies the onset depression: effect of water immersion stress on the rat2013

    • Author(s)
      Suzuki K, Rakwal R, Shibato J, Masuo Y
    • Organizer
      Neuro2013(第36回日本神経科学大会・第56回日本神経化学会大会・第23回日本神経回路学会大会 合同大会)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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