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Analyzing Fetal Origin of Adult Diseases Theory using Caenorhabditis elegans.

Research Project

Project/Area Number 24650507
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionKyoto Women's University

Principal Investigator

MATSUMOTO Shinya  京都女子大学, 家政学部, 准教授 (30263156)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords線虫 / Caenorhabditis elegans / 成人病胎児期起源説 / 低出生体重 / エピジェネティクス / 飢餓 / 成人病胎児起源説
Research Abstract

Fetal-Origin of Adult Diseases (FOAD) has been suggested as the third factor, in addition to genetic and environmental, that contributes to the establishment of life-style related disease. The basis of the theory is that nutritional condition in early stage of life may trigger the epigenetic modification in the genome, which leads to obese in adult stage. The precise mechanism of the theory, however, remains to be understood. This project was performed to explore the usefulness of Caenorhabditis elegans as a model system to study the FOAD.
In this project, it was shown that the progeny of starvation-experienced worms accumulated more fat compared to those of normally-fed worms using fluorescent dye Nile Red. The actual fat content, determined by gas chromatography, supported the increment of fat in the second generation of starvation-experienced worms. These data indicates that worms can be a suitable model system to study FOAD theory.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (12 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results) Book (5 results) Remarks (2 results)

  • [Journal Article] Non-specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense2013

    • Author(s)
      Kohta Ohnishi, Shinya Ohkura, Erina Nakahata, Akira Ishisaka, Yoshichika Kawai, Junji Terao, Taiki Mori, Takeshi Ishii, Tsutomu Nakayama, Noriyuki Kioka, Shinya Matsumoto, Yasutake Ikeda, Minoru Akiyama, Kazuhiro Irie, Akira Murakami
    • Journal Title

      PLOS ONE

      Volume: 8 Pages: 1-15

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-specific protein modifications by a phytochemical induce heat shock response for self-defense2013

    • Author(s)
      Kohta Ohnishi
    • Journal Title

      PLoS One

      Volume: 8(3) Issue: 3 Pages: 1-15

    • DOI

      10.1371/journal.pone.0058641

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 長期的な酸化脂質摂取が線虫の生殖能力と寿命に与える影響2012

    • Author(s)
      木村理恵, 麻生知子, 相馬顕子, 森友彦, 松村康生, 松本晋也
    • Journal Title

      京都女子大学食物学会誌

      Volume: 67 Pages: 37-44

    • NAID

      120005284941

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Effect of repeated starvation on fat content in C.elegans2013

    • Author(s)
      Shinya Matsumoto, Kosuke Kato, Yasuki Matsumura, Nao Sato, Yukari Yamamoto, Akari Sawanaga
    • Organizer
      19th International C.elegans Meeting
    • Place of Presentation
      UCLA(Los Angeles, USA)
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of repeated starvation on fat content in C.elegans.2013

    • Author(s)
      Shinya Matsumoto
    • Organizer
      19th International C.elegans Worm Meeting
    • Place of Presentation
      UCLA(Los Angeles,USA)
    • Related Report
      2013 Annual Research Report
  • [Book] 健康と環境の科学, 担当執筆第1章2節2014

    • Author(s)
      有園幸司, 石橋弘志, 石橋康弘, 伊藤貴美子, 岡本誉士典, 甲斐穂高, 古賀伸幸, 柴田祥江, 杉原数美, 高尾雄二, 瀧口益史, 春山洋一, 松原斎樹, 松本晋也, 山元涼子, 川添貞治(編)
    • Publisher
      講談社
    • Related Report
      2013 Final Research Report
  • [Book] 健康と環境の科学2014

    • Author(s)
      川添禎浩(編),有園幸司,石橋弘志,石橋康弘,伊藤貴美子,岡本誉士典,甲斐穂高,古賀伸幸,柴田祥江,杉原数美,高尾雄二,瀧口益史,春山洋一,松原斎樹,松本晋也,山元涼子,川添禎浩
    • Total Pages
      171
    • Publisher
      講談社
    • Related Report
      2013 Annual Research Report
  • [Book] 新 食品・栄養科学シリーズ「基礎栄養学」2013

    • Author(s)
      灘本知憲,山崎克人,中西一起,小野廣紀,仲佐輝子,西川義之,土井裕司,松本晋也,山本周美
    • Total Pages
      218
    • Publisher
      化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] 新食品・栄養科学シリーズ基礎栄養学, 執筆担当第10章, 第11章2012

    • Author(s)
      松本晋也, 他多数, 灘本知憲, 仲佐輝子(共編)
    • Publisher
      化学同人
    • Related Report
      2013 Final Research Report
  • [Book] 食物学会誌2012

    • Author(s)
      松本晋也
    • Total Pages
      72
    • Publisher
      京都女子大学食物栄養学科
    • Related Report
      2012 Research-status Report
  • [Remarks] 京都女子大学家政学部食物栄養学科松本晋也

    • URL

      http://gyouseki-db.kyoto-wu.ac.jp/2/0000128/profile.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 京都女子大学家政学部食物栄養学科松本晋也

    • URL

      http://gyouseki-db.kyoto-wu.ac.jp/Profiles/2/0000128/profile.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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