| Project/Area Number |
24650507
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kyoto Women's University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 線虫 / Caenorhabditis elegans / 成人病胎児期起源説 / 低出生体重 / エピジェネティクス / 飢餓 / 成人病胎児起源説 |
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| Research Abstract |
Fetal-Origin of Adult Diseases (FOAD) has been suggested as the third factor, in addition to genetic and environmental, that contributes to the establishment of life-style related disease. The basis of the theory is that nutritional condition in early stage of life may trigger the epigenetic modification in the genome, which leads to obese in adult stage. The precise mechanism of the theory, however, remains to be understood. This project was performed to explore the usefulness of Caenorhabditis elegans as a model system to study the FOAD.
In this project, it was shown that the progeny of starvation-experienced worms accumulated more fat compared to those of normally-fed worms using fluorescent dye Nile Red. The actual fat content, determined by gas chromatography, supported the increment of fat in the second generation of starvation-experienced worms. These data indicates that worms can be a suitable model system to study FOAD theory.
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